UCHL3

Name	ubiquitin C-terminal hydrolase L3
Structure
Novel Interactors	1 novel interactors: PKD2
Interactors	23 interactors: ATM ATXN7L3 CCNB1 CDH1 CEBPA FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5 YAP1
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Binding Deubiquitinase Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification
Pathways	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
GWAS	Diabetic retinopathy ( 23562823 ) Metabolite levels ( 23823483 )
Entrez ID	7347
HPRD ID	04367
Ensembl ID	ENSG00000118939
Uniprot IDs	A0A140VJZ4 P15374
PDB IDs	1UCH 1XD3 6ISU 6QML 7YV4
GO Terms Enriched among Interactors ?	Cellular Response To Gamma Radiation Post-translational Protein Modification Response To Gamma Radiation Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Protein Ubiquitination Response To Stress Cellular Response To Camptothecin Regulation Of Primary Metabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Ubiquitin Protein Ligase Activity Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lithium Ion Nucleoplasm Interleukin-6-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Lithium Ion Cysteine-type Deubiquitinase Activity Regulation Of DNA Repair Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Deubiquitination Telomere Maintenance Signal Transduction By P53 Class Mediator Response To Toxic Substance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Gland Development Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Deubiquitinase Activity Protein Polyubiquitination Protein Modification By Small Protein Removal DNA Damage Response