TFR2

Name	transferrin receptor 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: PRKAR2B
Interactors	7 interactors: CFTR DCLRE1B HFE OLFM4 SEC22A SOCS3 TF
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Transferrin Receptor Activity Protein Binding Co-receptor Binding
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis Receptor-mediated Endocytosis Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation
Pathways	Transferrin endocytosis and recycling
Drugs	Ferrous sulfate anhydrous Ferric derisomaltose
Diseases	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS	Apolipoprotein B levels ( 32203549 ) Eosinophil count ( 32888494 ) Hematocrit ( 19862010 28017375 32888494 27863252 ) Hematological parameters ( 19820697 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 28017375 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Iron status biomarkers ( 21208937 ) Iron status biomarkers (iron levels) ( 25352340 33536631 ) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 28017375 32888494 29403010 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 29403010 27863252 ) Mean corpuscular volume ( 19862010 32888494 27863252 28017375 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Red blood cell count ( 28017375 28453575 29403010 27863252 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte fraction of red cells ( 32888494 27863252 )
Entrez ID	7036
HPRD ID	05282
Ensembl ID	ENSG00000106327
Uniprot IDs	Q9UP52
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Multicellular Organismal-level Chemical Homeostasis HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Basal Part Of Cell Recycling Endosome Multicellular Organismal-level Iron Ion Homeostasis Response To Iron Ion Perinuclear Region Of Cytoplasm Iron Ion Transport Positive Regulation Of Receptor-mediated Endocytosis Early Endosome Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Intracellular Iron Ion Homeostasis Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Anion Channel Activity Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Antipsychotic Drug Telomeric Loop Formation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Multicellular Organismal-level Homeostasis Positive Regulation Of Monoatomic Anion Transport Regulation Of Receptor-mediated Endocytosis Response To Iron Ion Starvation Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Intracellular Chemical Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-lactamase Activity 5'-3' DNA Exonuclease Activity Telomeric 3' Overhang Formation Positive Regulation Of Hormone Secretion Transepithelial Water Transport Positive Regulation Of Endocytosis Cellular Homeostasis Positive Regulation Of Tooth Mineralization Regulation Of Iron Ion Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Metal Ion Bicarbonate Transmembrane Transporter Activity