PTGS2

Name	prostaglandin-endoperoxide synthase 2
Structure
Interactors	13 interactors: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Neuron Projection
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Embryo Implantation Regulation Of Blood Pressure Response To Nematode Response To Selenium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Prostaglandin Secretion Regulation Of Cell Population Proliferation Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Decidualization Regulation Of Inflammatory Response Brown Fat Cell Differentiation Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Pathways	Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs	Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases	Esophageal cancer Penile cancer Cholangiocarcinoma
GWAS	Crohn's disease ( 26192919 ) Inflammatory bowel disease ( 26192919 ) Knee osteoarthritis ( 18471798 )
Entrez ID	5743
HPRD ID	02599
Ensembl ID	ENSG00000073756
Uniprot IDs	P35354
PDB IDs	5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
GO Terms Enriched among Interactors ?	Negative Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Fibroblast Proliferation Regulation Of Post-translational Protein Modification Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Protein Deneddylation Regulation Of Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway MRNA 3'-UTR Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Neddylation Protein Modification By Small Protein Removal Protein Neddylation Glandular Epithelial Cell Differentiation Disordered Domain Specific Binding Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Oxygen Levels Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Fibroblast Proliferation COP9 Signalosome Regulation Of Programmed Necrotic Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Fibroblast Proliferation Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Telomere Maintenance Via Telomerase Regulation Of Calcium Ion Import Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Neuroblast Proliferation Positive Regulation Of Programmed Cell Death Regulation Of Calcium Ion Transport Negative Regulation Of Epithelial Cell Differentiation Gastrulation Inward Rectifier Potassium Channel Inhibitor Activity Basolateral Plasma Membrane Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Autophagosome Size Prostaglandin-I Synthase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of RNA Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway