ABCC1

Name	ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Structure
Novel Interactors	1 novel interactors: TNFRSF17
Interactors	7 interactors: ATP5F1A AZGP1 CSNK2A1 FILNC1 NPM1 NR3C1 TRAF3
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sphingolipid Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Leukotriene Metabolic Process Xenobiotic Metabolic Process Lipid Transport Response To Xenobiotic Stimulus Cobalamin Transport Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Carboxylic Acid Transport Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Cyclic Nucleotide Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways	Sphingolipid de novo biosynthesis Heme degradation Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1 Paracetamol ADME Transport of RCbl within the body NFE2L2 regulating MDR associated enzymes
Drugs	ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4
GWAS	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31152163 ) Hip circumference adjusted for BMI ( 34021172 ) Ischemic stroke (undetermined subtype) ( 26708676 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Multiple myeloma (survival) ( 26198393 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Psychosis proneness (perceptual aberration scale) ( 28525603 ) Rate of ventricular enlargement ( 31711042 ) Red cell distribution width ( 32888494 ) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186 ) Serum metabolite levels ( 33031748 ) Severe autoimmune type 2 diabetes ( 34737425 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) White blood cell count (basophil) ( 27863252 )
Entrez ID	4363
HPRD ID	01153
Ensembl ID	ENSG00000103222
Uniprot IDs	A0A7I2V2E0 P33527
PDB IDs	2CBZ 4C3Z 8VT4 8VUX 8VVC
GO Terms Enriched among Interactors ?	Core Promoter Sequence-specific DNA Binding Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Hsp90 Protein Binding Macrophage Differentiation Adenyl Ribonucleotide Binding Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To Steroid Hormone Stimulus Protein Kinase Binding Regulation Of Endoribonuclease Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator