TRIM74

Name	tripartite motif containing 74
Structure	No pdb structure
Interactors	11 interactors: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response
GWAS	No GWAS studies recorded
Entrez ID	378108
HPRD ID	15567
Ensembl ID	ENSG00000155428
Uniprot IDs	Q86UV6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Ubiquitin-modified Histone Reader Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Cysteine-type Deubiquitinase Activity Ubiquitin Protein Ligase Binding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Removal Regulation Of Signal Transduction By P53 Class Mediator Cysteine-type Peptidase Activity Regulation Of Signal Transduction Viral Budding Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Type I Interferon Production Regulation Of Organelle Assembly Protein Monoubiquitination Endosome To Lysosome Transport Regulation Of Intracellular Signal Transduction Autophagy Cysteine-type Endopeptidase Activity Positive Regulation Of TORC1 Signaling Cytoplasm Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Antifungal Innate Immune Response Positive Regulation Of TOR Signaling Nuclear Body Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of TORC1 Signaling Positive Regulation Of Protein Autoubiquitination VCB Complex Ubiquitin Ligase Complex BRCA1-B Complex