S1PR1

Name	sphingosine-1-phosphate receptor 1
Structure
Interactors	9 interactors: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft Presynapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration
Pathways	Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS
Drugs	Fingolimod Ponesimod Siponimod Ozanimod
GWAS	Irritable bowel syndrome ( 29673008 ) Lymphocyte count ( 27863252 29403010 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376 ) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376 ) Sensorimotor dexterity ( 31596458 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 )
Entrez ID	1901
HPRD ID	03578
Ensembl ID	ENSG00000170989
Uniprot IDs	P21453
PDB IDs	3V2W 3V2Y 7EO2 7EO4 7EVY 7EVZ 7EW0 7EW7 7TD3 7TD4 7VIE 7VIF 7VIG 7VIH 7WF7 8G94 8YIC
GO Terms Enriched among Interactors ?	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Gi/o-coupled Serotonin Receptor Activity Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Binding Cellular Response To Growth Factor Stimulus Peptidase Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Response To Growth Factor Regulation Of Small Molecule Metabolic Process Serotonin Receptor Activity Regulation Of Metal Ion Transport G Protein-coupled Serotonin Receptor Activity Enzyme Binding Guanyl Nucleotide Binding Neurotransmitter Receptor Activity Regulation Of Transport Positive Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Prostaglandin E Cell Cortex Reactive Nitrogen Species Metabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Monoatomic Ion Transport Regulation Of System Process Vasoconstriction Positive Regulation Of Proteolysis Plasma Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Cell Motility Response To Ketone