PARK7

Name	Parkinsonism associated deglycase
Structure
Novel Interactors	1 novel interactors: POLE2
Interactors	25 interactors: BAX BBS1 BCL2L1 CASP8 COXFA4 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 PIAS2 PINK1 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Membrane PML Body Axon Neuron Projection Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Enzyme Activator Activity Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Hydrolase Activity Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Peptidase Inhibitor Activity Signaling Receptor Activator Activity Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Cadherin Binding Mercury Ion Binding Nuclear Androgen Receptor Binding Peroxiredoxin Activity Ubiquitin-protein Transferase Inhibitor Activity Scaffold Protein Binding DNA-binding Transcription Factor Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity
	Biological Process	Synaptic Transmission, Dopaminergic Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Proteolysis Autophagy Inflammatory Response DNA Damage Response Response To Oxidative Stress Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lactate Biosynthetic Process Removal Of Superoxide Radicals Insulin Secretion Protein Repair Androgen Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To Glyoxal Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Glucose Homeostasis Hydrogen Peroxide Metabolic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Membrane Hyperpolarization Regulation Of Androgen Receptor Signaling Pathway Detoxification Of Hydrogen Peroxide Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs	Copper
Diseases	Parkinson's disease (PD)
GWAS	Behcet's disease ( 33393726 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Ischemic stroke ( 24262325 ) Ulcerative colitis ( 21297633 28067908 )
Entrez ID	11315
HPRD ID	03961
Ensembl ID	ENSG00000116288
Uniprot IDs	Q99497 V9HWC2
PDB IDs	1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62 7PA2 7PA3 8PPW 8PQ0 9CEI 9CFI 9CFM 9CFO 9CFQ 9CFY 9CFZ 9CG0 9CGA 9CGB 9CGD 9CGE 9CGF 9CGG 9CMX 9CMY
GO Terms Enriched among Interactors ?	Extrinsic Apoptotic Signaling Pathway Small Protein Activating Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death PML Body Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Intracellular Signal Transduction Protein Sumoylation Response To Stress Mitochondrion Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Cadmium Ion Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytoplasm Nucleus Apoptotic Signaling Pathway Response To Heat Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-containing Complex Mitochondrial Outer Membrane Death Effector Domain Binding Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Response To Copper Ion Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Communication