FST

Name	follistatin
Structure
Interactors	14 interactors: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Positive Regulation Of Hair Follicle Development Cellular Response To Growth Factor Stimulus
Pathways	Antagonism of Activin by Follistatin
Drugs	D-Myo-Inositol-Hexasulphate
GWAS	Acne (severe) ( 24927181 30542056 ) Alzheimer's disease (late onset) ( 30820047 ) Central corneal thickness ( 32528159 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) High-grade serous ovarian cancer ( 31469419 ) Intraocular pressure ( 29235454 29617998 ) Keratoconus ( 33649486 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Midgestational circulating levels of PCBs ( 28235828 ) Optic disc size ( 31809533 ) Refractive error ( 32231278 ) Vaginal microbiome composition (community state type) ( 32723796 )
Entrez ID	10468
HPRD ID	00641
Ensembl ID	ENSG00000134363
Uniprot IDs	P19883
PDB IDs	2B0U 2P6A 3HH2 5JHW
GO Terms Enriched among Interactors ?	Inhibin A Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Growth Factor Activity Regulation Of Follicle-stimulating Hormone Secretion Hemoglobin Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of B Cell Differentiation Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Macrophage Differentiation Cytokine Activity Hemoglobin Metabolic Process Hormone Activity Regulation Of Macrophage Differentiation Signaling Receptor Binding Activin Receptor Signaling Pathway Negative Regulation Of B Cell Activation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Endodermal Cell Differentiation Regulation Of B Cell Differentiation Reproductive Structure Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Leukocyte Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Immune System Process Negative Regulation Of Cell Activation Semicircular Canal Formation Inhibin B Complex Ovarian Follicle Development Negative Regulation Of Myeloid Leukocyte Differentiation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hormone Secretion Erythrocyte Differentiation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Positive Regulation Of Ovulation Progesterone Secretion Thymidine Kinase Activity Cellular Detoxification Of Hydrogen Peroxide Negative Regulation Of Multicellular Organismal Process Neural Fold Elevation Formation Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate