ST3GAL1 and GSTA1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
glutathione S-transferase alpha 1 |
- Keratan sulfate/keratin metabolism
- MPS I - Hurler syndrome
- MPS IX - Natowicz syndrome
- Glycosaminoglycan metabolism
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- O-linked glycosylation
- Defective CHST14 causes EDS, musculocontractural type
- Myoclonic epilepsy of Lafora
- MPS IIID - Sanfilippo syndrome D
- Defective CHST6 causes MCDC1
- Glycogen storage diseases
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Keratan sulfate biosynthesis
- Diseases associated with glycosaminoglycan metabolism
- Mucopolysaccharidoses
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Post-translational protein modification
- Defective EXT2 causes exostoses 2
- Termination of O-glycan biosynthesis
- Synthesis of substrates in N-glycan biosythesis
- Asparagine N-linked glycosylation
- MPS IV - Morquio syndrome A
- Sialic acid metabolism
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Metabolism of carbohydrates
- O-linked glycosylation of mucins
- Diseases associated with N-glycosylation of proteins
- MPS VI - Maroteaux-Lamy syndrome
- MPS IIIB - Sanfilippo syndrome B
- Diseases of glycosylation
- Defective B4GALT7 causes EDS, progeroid type
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective SLC26A2 causes chondrodysplasias
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective PAPSS2 causes SEMD-PA
- Defective MAN1B1 causes MRT15
- MPS IIIA - Sanfilippo syndrome A
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- MPS IIIC - Sanfilippo syndrome C
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- MPS II - Hunter syndrome
- Defective CHST3 causes SEDCJD
- Defective B3GAT3 causes JDSSDHD
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective CHSY1 causes TPBS
- MPS IV - Morquio syndrome B
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- MPS VII - Sly syndrome
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- Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
- Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
- Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
- Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
- Defective UGT1A4 causes hyperbilirubinemia
- Glutathione conjugation
- Metabolic disorders of biological oxidation enzymes
- Phase II conjugation
- Defective UGT1A1 causes hyperbilirubinemia
- Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
- Biological oxidations
- Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
- Defective GGT1 causes Glutathionuria (GLUTH)
- Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
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- Glutathione
- S-Hydroxycysteine
- 2-Hydroxyethyl Disulfide
- N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine
- Glutathione Sulfonic Acid
- S-Benzyl-Glutathione
- S-Hexylglutathione
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GNB1 and HDAC4 |
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
histone deacetylase 4 |
- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- ADP signalling through P2Y purinoceptor 1
- Integration of energy metabolism
- G alpha (s) signalling events
- Activation of GABAB receptors
- Glucagon-type ligand receptors
- G beta:gamma signalling through PLC beta
- Signaling by Wnt
- Metabolic disorders of biological oxidation enzymes
- G protein gated Potassium channels
- Olfactory Signaling Pathway
- Gastrin-CREB signalling pathway via PKC and MAPK
- Thromboxane signalling through TP receptor
- G alpha (z) signalling events
- G alpha (i) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- ADP signalling through P2Y purinoceptor 12
- Glucagon signaling in metabolic regulation
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Inwardly rectifying K+ channels
- G-protein beta:gamma signalling
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Aquaporin-mediated transport
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (q) signalling events
- GPCR downstream signaling
- Platelet homeostasis
- Platelet activation, signaling and aggregation
- Transmission across Chemical Synapses
- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signal amplification
- Potassium Channels
- Activation of the phototransduction cascade
- Inactivation, recovery and regulation of the phototransduction cascade
- G beta:gamma signalling through PI3Kgamma
- The phototransduction cascade
- G alpha (12/13) signalling events
- Class B/2 (Secretin family receptors)
- Prostacyclin signalling through prostacyclin receptor
- GABA B receptor activation
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- GPCR ligand binding
- beta-catenin independent WNT signaling
- Thrombin signalling through proteinase activated receptors (PARs)
- Presynaptic function of Kainate receptors
- Visual phototransduction
- Ca2+ pathway
- G-protein activation
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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GNB1 and CACNA1C |
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- ADP signalling through P2Y purinoceptor 1
- Integration of energy metabolism
- G alpha (s) signalling events
- Activation of GABAB receptors
- Glucagon-type ligand receptors
- G beta:gamma signalling through PLC beta
- Signaling by Wnt
- Metabolic disorders of biological oxidation enzymes
- G protein gated Potassium channels
- Olfactory Signaling Pathway
- Gastrin-CREB signalling pathway via PKC and MAPK
- Thromboxane signalling through TP receptor
- G alpha (z) signalling events
- G alpha (i) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- ADP signalling through P2Y purinoceptor 12
- Glucagon signaling in metabolic regulation
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Inwardly rectifying K+ channels
- G-protein beta:gamma signalling
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Aquaporin-mediated transport
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (q) signalling events
- GPCR downstream signaling
- Platelet homeostasis
- Platelet activation, signaling and aggregation
- Transmission across Chemical Synapses
- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signal amplification
- Potassium Channels
- Activation of the phototransduction cascade
- Inactivation, recovery and regulation of the phototransduction cascade
- G beta:gamma signalling through PI3Kgamma
- The phototransduction cascade
- G alpha (12/13) signalling events
- Class B/2 (Secretin family receptors)
- Prostacyclin signalling through prostacyclin receptor
- GABA B receptor activation
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- GPCR ligand binding
- beta-catenin independent WNT signaling
- Thrombin signalling through proteinase activated receptors (PARs)
- Presynaptic function of Kainate receptors
- Visual phototransduction
- Ca2+ pathway
- G-protein activation
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- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
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- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
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GNB1 and DISC1 |
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
disrupted in schizophrenia 1 |
- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- ADP signalling through P2Y purinoceptor 1
- Integration of energy metabolism
- G alpha (s) signalling events
- Activation of GABAB receptors
- Glucagon-type ligand receptors
- G beta:gamma signalling through PLC beta
- Signaling by Wnt
- Metabolic disorders of biological oxidation enzymes
- G protein gated Potassium channels
- Olfactory Signaling Pathway
- Gastrin-CREB signalling pathway via PKC and MAPK
- Thromboxane signalling through TP receptor
- G alpha (z) signalling events
- G alpha (i) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- ADP signalling through P2Y purinoceptor 12
- Glucagon signaling in metabolic regulation
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Inwardly rectifying K+ channels
- G-protein beta:gamma signalling
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Aquaporin-mediated transport
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (q) signalling events
- GPCR downstream signaling
- Platelet homeostasis
- Platelet activation, signaling and aggregation
- Transmission across Chemical Synapses
- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signal amplification
- Potassium Channels
- Activation of the phototransduction cascade
- Inactivation, recovery and regulation of the phototransduction cascade
- G beta:gamma signalling through PI3Kgamma
- The phototransduction cascade
- G alpha (12/13) signalling events
- Class B/2 (Secretin family receptors)
- Prostacyclin signalling through prostacyclin receptor
- GABA B receptor activation
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- GPCR ligand binding
- beta-catenin independent WNT signaling
- Thrombin signalling through proteinase activated receptors (PARs)
- Presynaptic function of Kainate receptors
- Visual phototransduction
- Ca2+ pathway
- G-protein activation
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PLCG1 and GRIN2A |
phospholipase C, gamma 1 |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- DAP12 signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Synthesis of IP3 and IP4 in the cytosol
- Signaling by FGFR1 mutants
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Signaling by PDGF
- DAP12 interactions
- Inositol phosphate metabolism
- Antiviral mechanism by IFN-stimulated genes
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- TCR signaling
- Signaling by VEGF
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Signaling by FGFR mutants
- Frs2-mediated activation
- Adaptive Immune System
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- DAG and IP3 signaling
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Downstream signaling of activated FGFR
- Netrin-1 signaling
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signalling by NGF
- Generation of second messenger molecules
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- PECAM1 interactions
- Cell surface interactions at the vascular wall
- Role of second messengers in netrin-1 signaling
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
- Constitutive Signaling by EGFRvIII
- Signaling by FGFR1 fusion mutants
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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PLCG1 and NTRK3 |
phospholipase C, gamma 1 |
neurotrophic tyrosine kinase, receptor, type 3 |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- DAP12 signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Synthesis of IP3 and IP4 in the cytosol
- Signaling by FGFR1 mutants
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Signaling by PDGF
- DAP12 interactions
- Inositol phosphate metabolism
- Antiviral mechanism by IFN-stimulated genes
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- TCR signaling
- Signaling by VEGF
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Signaling by FGFR mutants
- Frs2-mediated activation
- Adaptive Immune System
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- DAG and IP3 signaling
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Downstream signaling of activated FGFR
- Netrin-1 signaling
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signalling by NGF
- Generation of second messenger molecules
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- PECAM1 interactions
- Cell surface interactions at the vascular wall
- Role of second messengers in netrin-1 signaling
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
- Constitutive Signaling by EGFRvIII
- Signaling by FGFR1 fusion mutants
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RXRA and NFKB1 |
retinoid X receptor, alpha |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Bile acid and bile salt metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- Metabolic disorders of biological oxidation enzymes
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Generic Transcription Pathway
- Endogenous sterols
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Signaling by Retinoic Acid
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Regulation of pyruvate dehydrogenase (PDH) complex
- Pyruvate metabolism
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Activation of gene expression by SREBF (SREBP)
- The citric acid (TCA) cycle and respiratory electron transport
- Transcriptional activation of mitochondrial biogenesis
- PPARA activates gene expression
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Import of palmitoyl-CoA into the mitochondrial matrix
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Phase 1 - Functionalization of compounds
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Cytochrome P450 - arranged by substrate type
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Adapalene
- Bexarotene
- Acitretin
- Alitretinoin
- Etodolac
- Etretinate
- (5BETA)-PREGNANE-3,20-DIONE
- 2-chloro-5-nitro-N-phenylbenzamide
- 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- tributylstannanyl
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- Thalidomide
- Pranlukast
- Triflusal
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BTRC and NFKB1 |
beta-transducin repeat containing E3 ubiquitin protein ligase |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- Regulation of PLK1 Activity at G2/M Transition
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- RNF mutants show enhanced WNT signaling and proliferation
- Prolactin receptor signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Host Interactions of HIV factors
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Signaling by ERBB4
- APC/C-mediated degradation of cell cycle proteins
- Signaling by Interleukins
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Interleukin-1 signaling
- Mitotic G2-G2/M phases
- Adaptive Immune System
- Antigen processing: Ubiquitination & Proteasome degradation
- APC truncation mutants have impaired AXIN binding
- HIV Infection
- G2/M Transition
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- Class I MHC mediated antigen processing & presentation
- Vpu mediated degradation of CD4
- Cytokine Signaling in Immune system
- Cell Cycle, Mitotic
- Nuclear signaling by ERBB4
- TCF dependent signaling in response to WNT
- Activation of NF-kappaB in B cells
- SCF-beta-TrCP mediated degradation of Emi1
- Regulation of mitotic cell cycle
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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RXRA and HDAC4 |
retinoid X receptor, alpha |
histone deacetylase 4 |
- Bile acid and bile salt metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- Metabolic disorders of biological oxidation enzymes
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Generic Transcription Pathway
- Endogenous sterols
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Signaling by Retinoic Acid
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Regulation of pyruvate dehydrogenase (PDH) complex
- Pyruvate metabolism
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Activation of gene expression by SREBF (SREBP)
- The citric acid (TCA) cycle and respiratory electron transport
- Transcriptional activation of mitochondrial biogenesis
- PPARA activates gene expression
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Import of palmitoyl-CoA into the mitochondrial matrix
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Phase 1 - Functionalization of compounds
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Cytochrome P450 - arranged by substrate type
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
|
- Adapalene
- Bexarotene
- Acitretin
- Alitretinoin
- Etodolac
- Etretinate
- (5BETA)-PREGNANE-3,20-DIONE
- 2-chloro-5-nitro-N-phenylbenzamide
- 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- tributylstannanyl
|
|
|
|
RXRA and ARNTL |
retinoid X receptor, alpha |
aryl hydrocarbon receptor nuclear translocator-like |
- Bile acid and bile salt metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- Metabolic disorders of biological oxidation enzymes
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Generic Transcription Pathway
- Endogenous sterols
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Signaling by Retinoic Acid
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Regulation of pyruvate dehydrogenase (PDH) complex
- Pyruvate metabolism
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Activation of gene expression by SREBF (SREBP)
- The citric acid (TCA) cycle and respiratory electron transport
- Transcriptional activation of mitochondrial biogenesis
- PPARA activates gene expression
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Import of palmitoyl-CoA into the mitochondrial matrix
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Phase 1 - Functionalization of compounds
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Cytochrome P450 - arranged by substrate type
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- REV-ERBA represses gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- RORA activates circadian gene expression
|
- Adapalene
- Bexarotene
- Acitretin
- Alitretinoin
- Etodolac
- Etretinate
- (5BETA)-PREGNANE-3,20-DIONE
- 2-chloro-5-nitro-N-phenylbenzamide
- 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- tributylstannanyl
|
|
|
|
RAC1 and ARHGAP31 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
Rho GTPase activating protein 31 |
- Signaling by GPCR
- DCC mediated attractive signaling
- FCERI mediated MAPK activation
- Signaling by Wnt
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Sema4D induced cell migration and growth-cone collapse
- DAP12 interactions
- Host Interactions of HIV factors
- CD28 co-stimulation
- The role of Nef in HIV-1 replication and disease pathogenesis
- Factors involved in megakaryocyte development and platelet production
- GPCR downstream signaling
- Signaling by VEGF
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Adaptive Immune System
- Axon guidance
- Costimulation by the CD28 family
- HIV Infection
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Inactivation of Cdc42 and Rac
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Sema4D mediated inhibition of cell attachment and migration
- G alpha (12/13) signalling events
- Sema4D in semaphorin signaling
- Netrin-1 signaling
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Cell death signalling via NRAGE, NRIF and NADE
- Semaphorin interactions
- p75 NTR receptor-mediated signalling
- beta-catenin independent WNT signaling
- CD28 dependent Vav1 pathway
- DSCAM interactions
- NRAGE signals death through JNK
- GPVI-mediated activation cascade
- Signaling by Robo receptor
|
- Rho GTPase cycle
- Signaling by Rho GTPases
|
- Guanosine-5\'-Diphosphate
|
|
|
|
ITPR1 and BANK1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
B-cell scaffold protein with ankyrin repeats 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Integration of energy metabolism
- cGMP effects
- Signaling by Wnt
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Effects of PIP2 hydrolysis
- Platelet calcium homeostasis
- DAP12 signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Signaling by PDGF
- DAP12 interactions
- Opioid Signalling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- G alpha (q) signalling events
- Signaling by EGFR
- GPCR downstream signaling
- Platelet homeostasis
- Signaling by VEGF
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- G alpha (q) signalling events
- DAG and IP3 signaling
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Downstream signaling of activated FGFR
- Nitric oxide stimulates guanylate cyclase
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- Regulation of insulin secretion
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- beta-catenin independent WNT signaling
- Signaling by FGFR
- Ca2+ pathway
- Elevation of cytosolic Ca2+ levels
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
|
|
|
|
|
|
RAC1 and PPP2R2B |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
protein phosphatase 2, regulatory subunit B, beta |
- Signaling by GPCR
- DCC mediated attractive signaling
- FCERI mediated MAPK activation
- Signaling by Wnt
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Sema4D induced cell migration and growth-cone collapse
- DAP12 interactions
- Host Interactions of HIV factors
- CD28 co-stimulation
- The role of Nef in HIV-1 replication and disease pathogenesis
- Factors involved in megakaryocyte development and platelet production
- GPCR downstream signaling
- Signaling by VEGF
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Adaptive Immune System
- Axon guidance
- Costimulation by the CD28 family
- HIV Infection
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Inactivation of Cdc42 and Rac
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Sema4D mediated inhibition of cell attachment and migration
- G alpha (12/13) signalling events
- Sema4D in semaphorin signaling
- Netrin-1 signaling
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Cell death signalling via NRAGE, NRIF and NADE
- Semaphorin interactions
- p75 NTR receptor-mediated signalling
- beta-catenin independent WNT signaling
- CD28 dependent Vav1 pathway
- DSCAM interactions
- NRAGE signals death through JNK
- GPVI-mediated activation cascade
- Signaling by Robo receptor
|
|
- Guanosine-5\'-Diphosphate
|
|
|
|
RAC1 and BAG6 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
BCL2-associated athanogene 6 |
- Signaling by GPCR
- DCC mediated attractive signaling
- FCERI mediated MAPK activation
- Signaling by Wnt
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Sema4D induced cell migration and growth-cone collapse
- DAP12 interactions
- Host Interactions of HIV factors
- CD28 co-stimulation
- The role of Nef in HIV-1 replication and disease pathogenesis
- Factors involved in megakaryocyte development and platelet production
- GPCR downstream signaling
- Signaling by VEGF
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Adaptive Immune System
- Axon guidance
- Costimulation by the CD28 family
- HIV Infection
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Inactivation of Cdc42 and Rac
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Sema4D mediated inhibition of cell attachment and migration
- G alpha (12/13) signalling events
- Sema4D in semaphorin signaling
- Netrin-1 signaling
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Cell death signalling via NRAGE, NRIF and NADE
- Semaphorin interactions
- p75 NTR receptor-mediated signalling
- beta-catenin independent WNT signaling
- CD28 dependent Vav1 pathway
- DSCAM interactions
- NRAGE signals death through JNK
- GPVI-mediated activation cascade
- Signaling by Robo receptor
|
|
- Guanosine-5\'-Diphosphate
|
|
|
|
CDK7 and CTDP1 |
cyclin-dependent kinase 7 |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
|
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- Pausing and recovery of Tat-mediated HIV elongation
- Formation of RNA Pol II elongation complex
- HIV elongation arrest and recovery
- HIV Life Cycle
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- HIV Transcription Elongation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
|
- Phosphonothreonine
- Flavopiridol
|
|
|
|
CDK7 and HLA-DQA1 |
cyclin-dependent kinase 7 |
major histocompatibility complex, class II, DQ alpha 1 |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
|
- Generation of second messenger molecules
- Downstream TCR signaling
- Costimulation by the CD28 family
- Translocation of ZAP-70 to Immunological synapse
- Interferon Signaling
- Cytokine Signaling in Immune system
- Interferon gamma signaling
- TCR signaling
- MHC class II antigen presentation
- PD-1 signaling
- Phosphorylation of CD3 and TCR zeta chains
- Adaptive Immune System
|
- Phosphonothreonine
- Flavopiridol
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|
|
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FGF7 and NRP1 |
fibroblast growth factor 7 |
neuropilin 1 |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- SHC-mediated cascade
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Signaling by FGFR2 mutants
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- PI3K/AKT activation
- PI-3K cascade
- PI3K Cascade
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- Activated point mutants of FGFR2
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- FGFR ligand binding and activation
- FGFR2b ligand binding and activation
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- IRS-mediated signalling
- FGFR2 ligand binding and activation
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PI3K Cascade
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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MNAT1 and TRIM26 |
MNAT CDK-activating kinase assembly factor 1 |
tripartite motif containing 26 |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
|
- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
|
|
|
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CCNH and CTD |
cyclin H |
Coats disease |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
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CDK7 and CTD |
cyclin-dependent kinase 7 |
Coats disease |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
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- Phosphonothreonine
- Flavopiridol
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