JAK2 and IL3RA |
Janus kinase 2 |
interleukin 3 receptor, alpha (low affinity) |
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Prolactin receptor signaling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Downstream signal transduction
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- RMTs methylate histone arginines
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Nuclear signaling by ERBB4
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- G-protein beta:gamma signalling
- Chromatin organization
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Factors involved in megakaryocyte development and platelet production
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Chromatin modifying enzymes
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Growth hormone receptor signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
|
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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JAK1 and IL3RA |
Janus kinase 1 |
interleukin 3 receptor, alpha (low affinity) |
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Interleukin-7 signaling
- SOS-mediated signalling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Downstream signal transduction
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- ISG15 antiviral mechanism
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- G-protein beta:gamma signalling
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Interferon alpha/beta signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
|
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
|
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MAP2K1 and TRAF3 |
mitogen-activated protein kinase kinase 1 |
TNF receptor-associated factor 3 |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- ERK1 activation
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-1 signaling
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
- K-252a
- 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
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PIK3R1 and CSF2RA |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
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CALM1 and NT5C2 |
calmodulin 1 (phosphorylase kinase, delta) |
5-nucleotidase, cytosolic II |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
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- Purine catabolism
- Purine metabolism
- Metabolism of nucleotides
- Abacavir transport and metabolism
- Abacavir metabolism
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- Adenosine triphosphate
- Ribavirin
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PIK3R1 and ANK3 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
ankyrin 3, node of Ranvier (ankyrin G) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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- Interaction between L1 and Ankyrins
- Axon guidance
- L1CAM interactions
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- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
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CALM1 and TCF4 |
calmodulin 1 (phosphorylase kinase, delta) |
transcription factor 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
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- CDO in myogenesis
- Myogenesis
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CALM2 and TCF4 |
calmodulin 2 (phosphorylase kinase, delta) |
transcription factor 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
|
- CDO in myogenesis
- Myogenesis
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CALM3 and TCF4 |
calmodulin 3 (phosphorylase kinase, delta) |
transcription factor 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
|
- CDO in myogenesis
- Myogenesis
|
- Dibucaine
- Nicardipine
- Fluphenazine
- Isoflurane
- Trifluoperazine
- Loperamide
- Perphenazine
- Phenoxybenzamine
- Felodipine
- Melatonin
- Promethazine
- Pimozide
- Nifedipine
- Bepridil
- Calcium
- Aprindine
- 3\'\'-(Beta-Chloroethyl)-2\'\',4\'\'-Dioxo-3, 5\'\'-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine
- 2-Methyl-2-Propanol
- N-Trimethyllysine
- N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
- Prenylamine
- Flunarizine
- (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE
- MYRISTIC ACID
|
|
|
|
CALM1 and NRGN |
calmodulin 1 (phosphorylase kinase, delta) |
neurogranin (protein kinase C substrate, RC3) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
|
|
|
|
|
|
PRKACA and NFKB1 |
protein kinase, cAMP-dependent, catalytic, alpha |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
|
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
|
- Thalidomide
- Pranlukast
- Triflusal
|
|
|
PRKACA and CACNB2 |
protein kinase, cAMP-dependent, catalytic, alpha |
calcium channel, voltage-dependent, beta 2 subunit |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
|
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
- Transmission across Chemical Synapses
- Adrenaline,noradrenaline inhibits insulin secretion
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|
|
|
|
PRKACA and CACNA1C |
protein kinase, cAMP-dependent, catalytic, alpha |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
|
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
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|
PRKACA and GABRR1 |
protein kinase, cAMP-dependent, catalytic, alpha |
gamma-aminobutyric acid (GABA) A receptor, rho 1 |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
|
- GABA receptor activation
- GABA A (rho) receptor activation
- Ion channel transport
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ligand-gated ion channel transport
- Transmission across Chemical Synapses
|
|
- Lorazepam
- Temazepam
- Clobazam
- Alprazolam
- Picrotoxin
- Chlordiazepoxide
- Adinazolam
- Clorazepate
- Midazolam
- Flurazepam
- Halazepam
- Diazepam
- Oxazepam
- Triazolam
- Clonazepam
- Estazolam
- Bromazepam
- Clotiazepam
- Fludiazepam
- Prazepam
- Quazepam
- Cinolazepam
- Nitrazepam
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|
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SOS1 and TNIK |
son of sevenless homolog 1 (Drosophila) |
TRAF2 and NCK interacting kinase |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- SHC-mediated cascade
- FCERI mediated MAPK activation
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Regulation of KIT signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signalling to RAS
- Downstream signal transduction
- Signaling by Rho GTPases
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- Signalling to ERKs
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- Rho GTPase cycle
- IRS-related events triggered by IGF1R
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- Activation of Rac
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- NCAM signaling for neurite out-growth
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cell death signalling via NRAGE, NRIF and NADE
- SOS-mediated signalling
- SHC-mediated signalling
- Integrin alphaIIb beta3 signaling
- p75 NTR receptor-mediated signalling
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- SHC-related events
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- Signal attenuation
- NRAGE signals death through JNK
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- FCERI mediated Ca+2 mobilization
- Constitutive Signaling by EGFRvIII
- Signaling by Robo receptor
|
- Oxidative Stress Induced Senescence
- Cellular Senescence
|
|
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YWHAB and PARD3 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
par-3 family cell polarity regulator |
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Rap1 signalling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- Regulation of mRNA stability by proteins that bind AU-rich elements
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Frs2-mediated activation
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- Translocation of GLUT4 to the plasma membrane
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- Programmed Cell Death
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Tristetraprolin (TTP) destabilizes mRNA
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Signaling by Hippo
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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HDAC1 and NFKB1 |
histone deacetylase 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- SMAD2/3 MH2 Domain Mutants in Cancer
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Degradation of beta-catenin by the destruction complex
- NoRC negatively regulates rRNA expression
- Generic Transcription Pathway
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Mitotic G1-G1/S phases
- truncations of AMER1 destabilize the destruction complex
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- TGFBR1 KD Mutants in Cancer
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- RNA Polymerase I Transcription Initiation
- APC truncation mutants have impaired AXIN binding
- RNA Polymerase I Promoter Clearance
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signalling by NGF
- HDACs deacetylate histones
- p75NTR negatively regulates cell cycle via SC1
- Loss of Function of SMAD2/3 in Cancer
- RNA Polymerase I Transcription
- TGFBR2 Kinase Domain Mutants in Cancer
- Epigenetic regulation of gene expression
- p75 NTR receptor-mediated signalling
- G0 and Early G1
- Negative epigenetic regulation of rRNA expression
- repression of WNT target genes
- Loss of Function of TGFBR1 in Cancer
- Cell Cycle, Mitotic
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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HDAC1 and MAD1L1 |
histone deacetylase 1 |
MAD1 mitotic arrest deficient-like 1 (yeast) |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- SMAD2/3 MH2 Domain Mutants in Cancer
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Degradation of beta-catenin by the destruction complex
- NoRC negatively regulates rRNA expression
- Generic Transcription Pathway
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Mitotic G1-G1/S phases
- truncations of AMER1 destabilize the destruction complex
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- TGFBR1 KD Mutants in Cancer
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- RNA Polymerase I Transcription Initiation
- APC truncation mutants have impaired AXIN binding
- RNA Polymerase I Promoter Clearance
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signalling by NGF
- HDACs deacetylate histones
- p75NTR negatively regulates cell cycle via SC1
- Loss of Function of SMAD2/3 in Cancer
- RNA Polymerase I Transcription
- TGFBR2 Kinase Domain Mutants in Cancer
- Epigenetic regulation of gene expression
- p75 NTR receptor-mediated signalling
- G0 and Early G1
- Negative epigenetic regulation of rRNA expression
- repression of WNT target genes
- Loss of Function of TGFBR1 in Cancer
- Cell Cycle, Mitotic
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- Mitotic Spindle Checkpoint
- Amplification of signal from the kinetochores
- Mitotic Prometaphase
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cell Cycle Checkpoints
- Mitotic Anaphase
- Mitotic Metaphase and Anaphase
- Cell Cycle, Mitotic
- M Phase
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HDAC1 and ENO1 |
histone deacetylase 1 |
enolase 1, (alpha) |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- SMAD2/3 MH2 Domain Mutants in Cancer
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Degradation of beta-catenin by the destruction complex
- NoRC negatively regulates rRNA expression
- Generic Transcription Pathway
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Mitotic G1-G1/S phases
- truncations of AMER1 destabilize the destruction complex
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- TGFBR1 KD Mutants in Cancer
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- RNA Polymerase I Transcription Initiation
- APC truncation mutants have impaired AXIN binding
- RNA Polymerase I Promoter Clearance
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signalling by NGF
- HDACs deacetylate histones
- p75NTR negatively regulates cell cycle via SC1
- Loss of Function of SMAD2/3 in Cancer
- RNA Polymerase I Transcription
- TGFBR2 Kinase Domain Mutants in Cancer
- Epigenetic regulation of gene expression
- p75 NTR receptor-mediated signalling
- G0 and Early G1
- Negative epigenetic regulation of rRNA expression
- repression of WNT target genes
- Loss of Function of TGFBR1 in Cancer
- Cell Cycle, Mitotic
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
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FYN and GRIN2A |
FYN proto-oncogene, Src family tyrosine kinase |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- DCC mediated attractive signaling
- Netrin mediated repulsion signals
- Signaling by EGFRvIII in Cancer
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Regulation of KIT signaling
- PI3K/AKT activation
- PI-3K cascade
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- FCGR activation
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- Host Interactions of HIV factors
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- The role of Nef in HIV-1 replication and disease pathogenesis
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Sema3A PAK dependent Axon repulsion
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- Platelet Adhesion to exposed collagen
- Axon guidance
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- HIV Infection
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- EPHA-mediated growth cone collapse
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- NCAM signaling for neurite out-growth
- Netrin-1 signaling
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signalling by NGF
- Semaphorin interactions
- CTLA4 inhibitory signaling
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- PECAM1 interactions
- CD28 dependent Vav1 pathway
- Signaling by FGFR
- Cell surface interactions at the vascular wall
- GPVI-mediated activation cascade
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- Dasatinib
- 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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