TNFSF15 and PTBP3

		TNFSF15	PTBP3
Description		TNF superfamily member 15	polypyrimidine tract binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Nucleus
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	MRNA Processing RNA Splicing Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of RNA Splicing Erythrocyte Maturation Regulation Of RNA Splicing Regulation Of Cell Differentiation
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Crohn's disease
GWAS		Asthma ( 32296059) Asthma (childhood onset) ( 34022066) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255) Inflammatory bowel disease ( 18758464 27569725 23128233) Leprosy ( 25642632 20018961) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196) Ulcerative colitis ( 21297633 20848476) Ulcerative colitis or Crohn's disease ( 21699788)	Obstetric antiphospholipid syndrome ( 28424481) Panic disorder ( 31712720)
Interacting Genes		2 interacting genes: TNFRSF25 TNFRSF6B	60 interacting genes: APP CD2BP2 LINC00624 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7C RBPMS SLC25A21-AS1
Entrez ID		9966	9991
HPRD ID		04956	09603
Ensembl ID		ENSG00000181634	ENSG00000119314
Uniprot IDs		A0A0U5JA19 O95150	O95758
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?		L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of Angiogenesis Regulation Of Vasculature Development MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Cytokine Production Regulation Of Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Metabolic Process
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