KIF14 and TUBG1

Number of citations of the paper that reports this interaction (PubMedID 25348260)
69

Data Source:
BioGRID (unspecified method)

		KIF14	TUBG1
Description		kinesin family member 14	tubulin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Plasma Membrane Membrane Midbody Spindle Midzone Flemming Body	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Tubulin Binding ATP Hydrolysis Activity Protein Kinase Binding PDZ Domain Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity
	Biological Process	Regulation Of Cell Growth Microtubule-based Movement Microtubule Depolymerization Mitotic Metaphase Chromosome Alignment Positive Regulation Of Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebellar Granular Layer Structural Organization Cerebellar Purkinje Cell Layer Structural Organization Cerebellar Cortex Development Hippocampus Development Olfactory Bulb Development Cell Proliferation In Forebrain Cerebral Cortex Development Regulation Of Cell Adhesion Regulation Of Cell Migration SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Myelination Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Regulation Of Rap Protein Signal Transduction Negative Regulation Of Integrin Activation Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Cell Division Regulation Of Cell Maturation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization
Pathways		RHO GTPases activate CIT RND2 GTPase cycle RND1 GTPase cycle	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Vinblastine
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Neurofibrillary tangles ( 31497858) Refractive error ( 32231278) Tandem gait ( 26219847)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		3 interacting genes: CLK1 TUBG1 TUBGCP2	31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		9928	7283
HPRD ID		06605	01853
Ensembl ID		ENSG00000118193	ENSG00000131462
Uniprot IDs		A0A384P5W4 Q15058	P23258
PDB IDs			1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P
Enriched GO Terms of Interacting Partners?		Gamma-tubulin Complex Microtubule Nucleation Cytoplasmic Microtubule Organization Cytoplasmic Microtubule Mitotic Cell Cycle Spindle Organization Microtubule Nucleator Activity Polar Microtubule Ciliary Basal Body Microtubule Gamma-tubulin Ring Complex Microtubule Cytoskeleton Organization Supramolecular Fiber Organization Microtubule Minus-end Binding Mitotic Spindle Microtubule Meiotic Spindle Organization Centrosome Pericentriolar Material Protein Serine/threonine/tyrosine Kinase Activity Non-motile Cilium Mitotic Sister Chromatid Segregation Microtubule-based Process Gamma-tubulin Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Spindle Microtubule Sister Chromatid Segregation Condensed Nuclear Chromosome Nuclear Chromosome Segregation Cytoskeleton Organization Cell Leading Edge Apical Part Of Cell Structural Constituent Of Cytoskeleton Reproductive Process Mitotic Spindle Organization Microtubule Organizing Center Spindle Assembly	Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading
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