URB2 and LMNB1

Number of citations of the paper that reports this interaction (PubMedID 15265697)
0

Data Source:
HPRD (in vitro)

		URB2	LMNB1
Description		URB2 ribosome biogenesis homolog	lamin B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Aggresome Midbody	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery
	Molecular Function		Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding
	Biological Process	Ribosome Biogenesis Regulation Of Signal Transduction By P53 Class Mediator	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways			Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Fasting blood insulin adjusted for BMI ( 25625282) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Sleep (1/3-day periodicity) ( 33075057)	Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		2 interacting genes: LMNA LMNB1	42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		9816	4001
HPRD ID		17178	01036
Ensembl ID		ENSG00000135763	ENSG00000113368
Uniprot IDs		Q14146	B4DZT3 P20700
PDB IDs			2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Lamina Lamin Filament Nuclear Pore Localization Nuclear Lamina Protein Localization To Nuclear Envelope Nuclear Envelope Organization Nuclear Migration Nucleus Localization Protein-containing Complex Localization Nucleus Organization Structural Constituent Of Cytoskeleton Nuclear Matrix Heterochromatin Formation Intermediate Filament Negative Regulation Of Gene Expression, Epigenetic Protein Localization To Nucleus Nuclear Envelope DNA Double-strand Break Attachment To Nuclear Envelope Establishment Of Organelle Localization Nuclear Membrane Epigenetic Regulation Of Gene Expression Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Organelle Localization Localization Within Membrane Negative Regulation Of Mesenchymal Cell Proliferation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Membrane Organization Protein Localization To Organelle Chromatin Remodeling Nuclear Periphery Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Chromatin Organization Phospholipase Binding Cytoskeleton Organization Regulation Of Mesenchymal Cell Proliferation Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Negative Regulation Of Gene Expression Intracellular Transport Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Nuclear Inner Membrane Cellular Senescence Cellular Localization Establishment Of Localization In Cell Striated Muscle Cell Development	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity
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