TEFM and SPCS2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TEFM	SPCS2
Gene Name		transcription elongation factor, mitochondrial	signal peptidase complex subunit 2 homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Complex Mitochondrial Nucleoid	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity DNA Polymerase Processivity Factor Activity Poly(A) RNA Binding	Peptidase Activity
	Biological Process	Oxidative Phosphorylation DNA Metabolic Process Mitochondrial DNA Replication Regulation Of Transcription, DNA-templated Transcription From Mitochondrial Promoter	Translation Signal Peptide Processing Proteolysis SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Cellular Protein Metabolic Process Regulation Of Insulin Secretion
Pathways			Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Translation Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PPP1CC SPCS2	5 interactors: ATP13A2 CLN8 EGFR STMN3 TEFM
Entrez ID		79736	9789
HPRD ID		08005	15435
Ensembl ID			ENSG00000118363
Uniprot IDs		Q96QE5	Q15005
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Triglyceride Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Circadian Rhythm Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus	Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation L-glutamate Uptake Involved In Synaptic Transmission Regulation Of Catalytic Activity Activation Of Phospholipase A2 Activity Cellular Response To Manganese Ion Positive Regulation Of Phospholipase A2 Activity Neuron Differentiation Age-dependent Response To Oxidative Stress Response To Cobalamin Response To UV-A Learning Or Memory Negative Regulation Of Rac Protein Signal Transduction Response To Hydroxyisoflavone Cognition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Somatic Motor Neuron Differentiation L-glutamate Import Response To Metal Ion Microtubule Depolymerization Positive Regulation Of Catenin Import Into Nucleus Transcription From Mitochondrial Promoter Regulation Of Phospholipase A2 Activity Generation Of Neurons Regulation Of Superoxide Anion Generation Neurotransmitter Uptake Mitochondrion Organization Neurofilament Cytoskeleton Organization Response To Oxidative Stress Neurogenesis Magnesium Ion Homeostasis Neuromuscular Process Controlling Posture Single-organism Behavior Amino Acid Import Response To Inorganic Substance Response To Manganese Ion Cellular Response To Estradiol Stimulus Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Catenin Import Into Nucleus Regulation Of Rac GTPase Activity Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Sensory Organ Development L-glutamate Transport Behavior
Tagcloud ?		c17orf42 coincident comprising dead dhx30 dsdna elongation foci helicase hereafter hhh incompetence makes mitochondria mitochondrial motifs owing pentatricopeptide polrmt processivity ptcd3 purification ribonuclease rnase spt6 ss strand templates transcripts
Tagcloud (Difference) ?		c17orf42 coincident comprising dead dhx30 dsdna elongation foci helicase hereafter hhh incompetence makes mitochondria mitochondrial motifs owing pentatricopeptide polrmt processivity ptcd3 purification ribonuclease rnase spt6 ss strand templates transcripts
Tagcloud (Intersection) ?