RIMS3 and GJA5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		RIMS3	GJA5
Name		regulating synaptic membrane exocytosis 3	gap junction protein alpha 5
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Presynaptic Membrane Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component	Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Small GTPase Binding Transmembrane Transporter Binding Structural Constituent Of Presynaptic Active Zone	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Neurotransmitter Transport Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Regulation Of Membrane Potential Maintenance Of Presynaptic Active Zone Structure Regulation Of Synaptic Vesicle Exocytosis	Skeletal System Development Angiogenesis Blood Vessel Development Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication Cell-cell Signaling Heart Development Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Cardiac Conduction Ventricular Cardiac Muscle Cell Action Potential SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication Involved In Cardiac Conduction AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion
Pathways		None	Gap junction assembly
Diseases		None	Atrial fibrillation
GWAS		No GWAS studies recorded	Atrial fibrillation ( 29892015 30061737 ) Cognitive performance ( 20125193 ) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057 ) PR interval ( 32439900 ) Triglyceride levels ( 34074324 )
Interacting Genes		7 interacting genes: BANP BCL2L2-PABPN1 CREB3 GJA5 MEOX2 PICK1 TRIM54	34 interacting genes: AAR2 ABHD16A ARLN BLCAP EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC61A1 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		9783	2702
HPRD ID		17976	08699
Ensembl ID		ENSG00000117016	ENSG00000265107
Uniprot IDs		Q9UJD0	P36382 X5D2H9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Positive Regulation Of Deacetylase Activity Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Striated Muscle Tissue Development Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Muscle Tissue Development Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Negative Regulation Of Cytoskeleton Organization Membrane Curvature Sensor Activity Negative Regulation Of Supramolecular Fiber Organization Gap Junction Hemi-channel Activity Connexin Binding Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Somite Specification Release From Viral Latency SA Node Cell Action Potential Atrioventricular Valve Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation CCR1 Chemokine Receptor Binding AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Membrane Depolarization During Action Potential Gap Junction Assembly Negative Regulation Of Actin Nucleation Atrial Septum Development Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization	Membrane Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Transmembrane Transport Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Inorganic Cation Transmembrane Transporter Activity Gap Junction Assembly Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein Binding Monoatomic Ion Transport Transmembrane Transporter Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Ion Transmembrane Transport Connexin Complex Gap Junction Channel Activity