PCLAF and UHRF1

Number of citations of the paper that reports this interaction (PubMedID 36734974)
74

Data Source:
BioGRID (enzymatic study)

		PCLAF	UHRF1
Description		PCNA clamp associated factor	ubiquitin like with PHD and ring finger domains 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Perinuclear Region Of Cytoplasm	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Spindle Nuclear Matrix
	Molecular Function	Chromatin Binding Protein Binding Molecular Adaptor Activity	Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Transferase Activity Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity DNA Damage Sensor Activity Histone H3 Ubiquitin Ligase Activity
	Biological Process	DNA Replication DNA Repair DNA Damage Response Centrosome Cycle Response To UV Translesion Synthesis Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Response To Stress DNA Damage Response Protein Ubiquitination Heterochromatin Formation Homologous Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Protein Autoubiquitination Mitotic Spindle Assembly
Pathways		Termination of translesion DNA synthesis	DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: CEBPA DNMT1 PCNA TERF1 UHRF1 USP7	36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7
Entrez ID		9768	29128
HPRD ID		13778	06992
Ensembl ID		ENSG00000166803	ENSG00000276043
Uniprot IDs		Q15004	A0A087WVR3 Q96T88
PDB IDs		4D2G 6EHT 6GWS 6IIW	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Replication Fork Regulation Of Establishment Of Protein Localization To Telomere Nucleic Acid Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Methyl-CpG Binding DNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization Epigenetic Regulation Of Gene Expression Response To Xenobiotic Stimulus Nucleobase-containing Compound Biosynthetic Process Response To Dexamethasone Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Regeneration DNA Binding Heterochromatin Nuclear Body Cellular Response To Xenobiotic Stimulus Organelle Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Regulation Of DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Histone H3 Ubiquitin Ligase Activity Chromatin Binding DNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Response To Vitamin B2 Liver Development C/EBP Complex Negative Regulation Of RNA Biosynthetic Process	Nucleoplasm Nucleus DNA Repair Nucleosome Chromosome Structural Constituent Of Chromatin Chromatin Organization Chromatin Remodeling DNA Metabolic Process DNA Damage Response DNA Binding Nucleosome Assembly Nucleosome Organization Cellular Response To Stress Chromosome Organization Protein Heterodimerization Activity Chromosome, Telomeric Region Protein-DNA Complex Assembly Macromolecule Metabolic Process Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process TORC1 Signaling Response To Radiation Negative Regulation Of TORC1 Signaling Protein-containing Complex Mitotic DNA Damage Checkpoint Signaling Protein Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ubiquitin Conjugating Enzyme Activity Response To UV TOR Signaling Cellular Response To Nutrient Levels Regulation Of Cell Cycle Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Stress Negative Regulation Of TOR Signaling
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