PCLAF

Name	PCNA clamp associated factor
Structure
Interactors	6 interactors: CEBPA DNMT1 PCNA TERF1 UHRF1 USP7
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Molecular Adaptor Activity
	Biological Process	DNA Replication DNA Repair DNA Damage Response Centrosome Cycle Response To UV Translesion Synthesis Regulation Of Cell Cycle
Pathways	Termination of translesion DNA synthesis
GWAS	No GWAS studies recorded
Entrez ID	9768
HPRD ID	13778
Ensembl ID	ENSG00000166803
Uniprot IDs	Q15004
PDB IDs	4D2G 6EHT 6GWS 6IIW
GO Terms Enriched among Interactors ?	Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Replication Fork Regulation Of Establishment Of Protein Localization To Telomere Nucleic Acid Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Methyl-CpG Binding DNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization Epigenetic Regulation Of Gene Expression Response To Xenobiotic Stimulus Nucleobase-containing Compound Biosynthetic Process Response To Dexamethasone Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Regeneration DNA Binding Heterochromatin Nuclear Body Cellular Response To Xenobiotic Stimulus Organelle Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Regulation Of DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Histone H3 Ubiquitin Ligase Activity Chromatin Binding DNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Response To Vitamin B2 Liver Development C/EBP Complex Negative Regulation Of RNA Biosynthetic Process