CARTPT and MRPS27

Data Source: HiPPIP (Novel)

		CARTPT	MRPS27
Name		CART prepropeptide	mitochondrial ribosomal protein S27
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Synapse	Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Molecular_function Neuropeptide Hormone Activity Protein Binding	TRNA Binding RNA Binding Protein Binding RRNA Binding
	Biological Process	Intracellular Glucose Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Adult Feeding Behavior Cellular Response To Starvation Positive Regulation Of Cell Communication Negative Regulation Of Appetite Positive Regulation Of Epinephrine Secretion Circadian Regulation Of Gene Expression Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Regulation Of Bone Remodeling Regulation Of Insulin Secretion Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Biological Quality Negative Regulation Of Glucagon Secretion Somatostatin Secretion	Regulation Of Translation Cell Population Proliferation Mitochondrial Translation
Pathways		None	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs		Amphetamine	None
GWAS		No GWAS studies recorded	Refractive error ( 32231278 )
Interacting Genes		4 interacting genes: CEACAM1 CEACAM6 MEIS2 SDHB	5 interacting genes: CFTR NECAB2 PTEN SNRNP48 YWHAQ
Entrez ID		9607	23107
HPRD ID		04006	17596
Ensembl ID		ENSG00000164326	ENSG00000113048
Uniprot IDs		Q16568	G5EA06 Q6PKB3 Q92552
PDB IDs		1HY9	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
GO Terms Enriched among Interactors		Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Granulocyte Colony-stimulating Factor Signaling Pathway Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Mitochondrial Electron Transport, Succinate To Ubiquinone Respiratory Chain Complex II (succinate Dehydrogenase) Ubiquinone Binding Regulation Of Myeloid Cell Differentiation Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Succinate Metabolic Process Bile Acid Transmembrane Transporter Activity Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Granulocyte Differentiation Regulation Of Blood Vessel Remodeling Negative Regulation Of Platelet Aggregation	Negative Regulation Of Transport 14-3-3 Protein Binding Regulation Of Transport Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding PDZ Domain Binding Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synapse Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Somatostatin Secretion Positive Regulation Of Epinephrine Secretion Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Regulation Of Nervous System Process Negative Regulation Of Glucagon Secretion Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Positive Regulation Of Enamel Mineralization Adult Behavior Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Insulin Secretion Transepithelial Water Transport Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Glucagon Secretion Developmental Maturation Identical Protein Binding Bicarbonate Transmembrane Transporter Activity Positive Regulation Of Cell Communication Intracellular PH Elevation