PITPNM1 and PRKRA

Data Source: HiPPIP (Novel)

		PITPNM1	PRKRA
Name		phosphatidylinositol transfer protein membrane associated 1	protein activator of interferon induced protein kinase EIF2AK2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane Midbody Cleavage Furrow Golgi Cisterna Membrane Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Transporter Activity Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Receptor Tyrosine Kinase Binding Phosphatidylcholine Binding Phosphatidylinositol Binding Metal Ion Binding Phosphatidic Acid Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Brain Development Phototransduction Protein Transport Phospholipid Transport Intermembrane Lipid Transfer	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of PI	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Refractive error ( 32231278 )	Inflammatory skin disease ( 25574825 ) Multiple sclerosis (OCB status) ( 23472185 ) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183 )
Novel Interactors		1 novel interactors: PRKRA	6 novel interactors: CAT CLASP1 FZD7 HEYL PITPNM1 PLEKHA3
Interacting Genes		5 interacting genes: CDK1 PLK1 PTK2B RHOA TFCP2	29 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 H19 LNX1 LYAR NEIL3 NKRF PIAS2 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		9600	8575
HPRD ID		07497	04573
Ensembl ID		ENSG00000110697	ENSG00000180228
Uniprot IDs		B2R787 O00562	A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569
PDB IDs		Not available	2DIX
GO Terms Enriched among Interactors		Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Nuclear Membrane Disassembly Golgi Organization Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Midbody Protein Localization To Site Of Double-strand Break Regulation Of Organelle Assembly Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Lymphocyte Migration Spindle Microtubule Chromosome Condensation Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Nuclear Membrane Organization Centrosome Cycle Cytoskeleton Organization Cell Cycle G2/M Phase Transition Protein Phosphorylation Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Modification Process Phosphorylation Mitotic Cytokinesis Regulation Of Lymphocyte Migration Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Organelle Organization Mitotic Cleavage Furrow Formation Microtubule Cytoskeleton Organization Cell Division Pronuclear Fusion Microtubule Organizing Center Organization Neurotransmitter Receptor Regulator Activity Regulation Of Cytokinesis Regulation Of Primary Metabolic Process Regulation Of Catalytic Activity Aortic Valve Formation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Organelle Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Cytoskeleton Organization	Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing