GTPBP1 and C7orf25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTPBP1	C7orf25
Description		GTP binding protein 1	chromosome 7 open reading frame 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasmic Exosome (RNase Complex) Cytoplasm Cytosol Membrane
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Alpha-aminoacyl-tRNA Binding	Protein Binding
	Biological Process	Cytoplasmic Translation Translational Elongation Immune Response Signal Transduction GTP Metabolic Process Positive Regulation Of MRNA Catabolic Process RNA Surveillance
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) C-reactive protein levels ( 30388399) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Mean reticulocyte volume ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Asthma ( 29273806) Ceramide levels (C24:0) ( 32489964)
Interacting Genes		5 interacting genes: APP C7orf25 CEBPA LRP1 WEE2-AS1	20 interacting genes: BRD4 CEP70 CRYM DACT1 EZH2 FRA10AC1 FYN FZR1 GTPBP1 HAP1 HEXD MTOR MX1 NGEF PTN RASSF1 RPL36AL SF3B2 TARS1 UBE2D1
Entrez ID		9567	79020
HPRD ID		03765	09861
Ensembl ID		ENSG00000100226	ENSG00000136197
Uniprot IDs		O00178	Q9BPX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Astrocyte Activation Involved In Immune Response Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding Regulation Of Amyloid-beta Clearance Astrocyte Activation Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Clathrin-coated Pit Cellular Response To Amyloid-beta Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Endocytosis	Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Projection Organization Regulation Of Protein Metabolic Process Positive Regulation Of Dendrite Development Regulation Of Cell Projection Organization Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Regulation Of Gliogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Ubiquitination Cytoplasmic Translation Ephrin Receptor Binding Positive Regulation Of Post-translational Protein Modification Delta1-piperideine-2-carboxylate Reductase Activity Nucleus Thiomorpholine-carboxylate Dehydrogenase Activity Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Protein Modification Process Hepatocyte Homeostasis Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Neurogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Translation Transmembrane Transporter Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Glial Cell Differentiation Regulation Of Protein Catabolic Process Pyrimidine-containing Compound Biosynthetic Process Regulation Of Oligodendrocyte Differentiation Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Neurotrophin Production Histone H4K8ac Reader Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Myelination T Cell Costimulation Regulation Of Cell Cycle Process Regulation Of Neuron Projection Development Cellular Response To Stress Regulation Of Nervous System Development Positive Regulation Of Cell Development Dendrite Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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