ERICH2 and MACROH2A1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ERICH2	MACROH2A1
Description		glutamate rich 2	macroH2A.1 histone
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Extracellular Exosome Site Of DNA Damage
	Molecular Function	Protein Binding	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding Poly-ADP-D-ribose Modification-dependent Protein Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Oxidative Phosphorylation DNA Repair Chromatin Organization Nucleosome Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Lipid Metabolic Process Heterochromatin Formation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Epigenetic Regulation Of Gene Expression Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Regulation Of RDNA Heterochromatin Formation Protein Poly-ADP-ribosylation Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of NAD Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: FBXO7 IWS1 MACROH2A1 PSORS1C2 SDCBP	21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622
Entrez ID		285141	9555
HPRD ID			13624
Ensembl ID		ENSG00000204334	ENSG00000113648
Uniprot IDs		A0A8V8TMA0 A0A8V8TMB5 A1L162	A0A994J4J7 B4DJC3 O75367
PDB IDs			1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC 7D3Y
Enriched GO Terms of Interacting Partners?		Interleukin-5 Receptor Complex Protein Heterodimerization Activity Negative Regulation Of Protein Localization To Chromosome, Telomeric Region Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Interleukin-5 Receptor Binding ADP-D-ribose Binding Regulation Of NAD Metabolic Process Regulation Of RDNA Heterochromatin Formation Positive Regulation Of Endodermal Cell Differentiation Positive Regulation Of Response To Oxidative Stress ADP-D-ribose Modification-dependent Protein Binding Lewy Body Core Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Targeting Regulation Of Extracellular Exosome Assembly Poly-ADP-D-ribose Modification-dependent Protein Binding RDNA Binding Sex Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Double-stranded Methylated DNA Binding Barr Body Transcription Elongation-coupled Chromatin Remodeling Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Response To Oxidative Stress Establishment Of Protein Localization To Chromatin Regulation Of Heterochromatin Formation Substrate-dependent Cell Migration, Cell Extension Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Sister Chromatid Cohesion Regulation Of MRNA Export From Nucleus Establishment Of Protein Localization Establishment Of Protein Localization To Organelle Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Exosomal Secretion Negative Regulation Of Receptor Internalization Regulation Of Sister Chromatid Cohesion Protein Poly-ADP-ribosylation Regulation Of RNA Export From Nucleus Regulation Of Exosomal Secretion Positive Regulation Of Keratinocyte Differentiation Cytoskeletal Anchor Activity	Histone H2AK127 Ubiquitin Ligase Activity Protein Polyubiquitination Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Chromatin Organization Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Chromatin Remodeling Ubiquitin Ligase Complex BRCA1-B Complex Protein Modification By Small Protein Conjugation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Ionizing Radiation Zinc Ion Binding BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Intrinsic Apoptotic Signaling Pathway Innate Immune Response Identical Protein Binding Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of RNA Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair DNA Recombination Protein Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Site Of Double-strand Break Chromatin Binding Ubiquitin-protein Transferase Activity DNA Damage Checkpoint Signaling Response To Other Organism Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA Damage Checkpoint Host-mediated Suppression Of Symbiont Invasion Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Ubiquitin Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process
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