SPAG7 and PDE2A

Data Source: HiPPIP (Novel)

		SPAG7	PDE2A
Name		sperm associated antigen 7	phosphodiesterase 2A
Structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		None	cGMP effects G alpha (s) signalling events
Drugs		None	Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
GWAS		Keratoconus ( 33649486 ) Mean platelet volume ( 27863252 ) Serum metabolite levels ( 33031748 )	Household income (MTAG) ( 31844048 ) Optic nerve measurement (cup area) ( 20395239 ) Rheumatoid arthritis ( 22446963 )
Novel Interactors		1 novel interactors: PDE2A	12 novel interactors: ANAPC15 CHEK1 FAM168A FCHSD2 FOLR1 GLS2 HSD17B6 LRP5 NDUFV1 RPS3 RPS6KA4 SPAG7
Interacting Genes		2 interacting genes: ABHD16A LXN	1 interacting genes: ITSN1
Entrez ID		9552	5138
HPRD ID		10247	04041
Ensembl ID		ENSG00000091640	ENSG00000186642
Uniprot IDs		O75391	O00408 Q8IW54
PDB IDs		2CPM	1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
GO Terms Enriched among Interactors		3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Organophosphate Catabolic Process Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Cellular Response To CGMP 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Cyclic Nucleotide Catabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Macrophage Colony-stimulating Factor Negative Regulation Of CGMP-mediated Signaling 3',5'-cyclic-GMP Phosphodiesterase Activity Phosphate Ion Binding Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus CAMP Binding CGMP Catabolic Process TPR Domain Binding Regulation Of CGMP-mediated Signaling Monocyte Differentiation 3',5'-cyclic-nucleotide Phosphodiesterase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine CGMP Binding Positive Regulation Of Vascular Permeability Negative Regulation Of Vascular Permeability Response To CGMP Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Monoacylglycerol Lipase Activity Phosphatidylserine Metabolic Process Monoacylglycerol Catabolic Process Phosphatidylcholine Lysophospholipase Activity Metalloendopeptidase Inhibitor Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Heart Valve Development Glycerophospholipid Catabolic Process Detection Of Temperature Stimulus Negative Regulation Of CAMP/PKA Signal Transduction Phospholipase Activity Acylglycerol Catabolic Process CGMP-mediated Signaling Modified Amino Acid Catabolic Process Aorta Development Ventricular Septum Development Establishment Of Endothelial Barrier Cyclic Purine Nucleotide Metabolic Process Organophosphate Metabolic Process Artery Development Cardiac Septum Development	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft