NRGN and EIF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NRGN	EIF5
Description		neurogranin	eukaryotic translation initiation factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Trans-Golgi Network Transport Vesicle Membrane Axon Dendrite Mitochondrial Membrane Neuronal Cell Body Dendritic Spine Head Postsynaptic Membrane Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Synapse
	Molecular Function	Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidic Acid Binding	Nucleotide Binding RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Signal Transduction Nervous System Development Associative Learning Telencephalon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation	Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		Long-term potentiation Long-term potentiation	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 19571808 25056061 28991256 29483656 30285260)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		6 interacting genes: CALM1 EIF5 GLP1R PRKCA PRKCB PRKCG	18 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1
Entrez ID		4900	1983
HPRD ID		03828	03417
Ensembl ID		ENSG00000154146	ENSG00000100664
Uniprot IDs		Q92686	P55010
PDB IDs			2E9H 2G2K 2IU1 8OZ0 8PJ2 8PJ3
Enriched GO Terms of Interacting Partners?		Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Presynaptic Cytosol Protein Kinase C Signaling Response To Psychosocial Stress Mitotic Nuclear Membrane Disassembly Nuclear Membrane Disassembly Membrane Disassembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Exocytosis Presynaptic Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Learning Or Memory Nuclear Membrane Organization Regulation Of Synaptic Vesicle Exocytosis Long-term Synaptic Potentiation G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Cognition Glucagon-like Peptide 1 Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Nervous System Process Positive Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Serine/threonine Kinase Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Protein Transport Response To Toxic Substance Signal Transduction Negative Regulation Of Transmembrane Transport Eukaryotic Initiation Factor EIF2 Binding Glucagon Receptor Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Mismatch Repair Regulation Of Intracellular Signal Transduction Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Intracellular Signal Transduction	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translation Translation Factor Activity, RNA Binding Cap-dependent Translational Initiation Post-transcriptional Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Cytosol RNA Binding Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein Metabolic Process Viral Translational Termination-reinitiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Positive Regulation Of Growth MRNA Binding Regulation Of Synapse Organization Sin3-type Complex Translation Initiation Factor Binding Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Catabolic Process Cellular Component Assembly Regulation Of Growth Regulation Of Presynapse Organization Regulation Of Presynapse Assembly PcG Protein Complex Post-transcriptional Gene Silencing Negative Regulation Of Proteolysis Viral Process
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