NRGN and EI24

Data Source: HiPPIP (Novel)

		NRGN	EI24
Name		neurogranin	EI24 autophagy associated transmembrane protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Trans-Golgi Network Transport Vesicle Membrane Axon Dendrite Mitochondrial Membrane Neuronal Cell Body Dendritic Spine Head Postsynaptic Membrane Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane
	Molecular Function	Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidic Acid Binding	Protein Binding Importin-alpha Family Protein Binding
	Biological Process	Signal Transduction Nervous System Development Associative Learning Telencephalon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation	Autophagy Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Macroautophagy Negative Regulation Of Cell Growth Negative Regulation Of Protein Import Into Nucleus Neuromuscular Process Controlling Balance Cellular Response To UV-C Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Long-term potentiation Long-term potentiation	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Schizophrenia ( 19571808 25056061 28991256 29483656 30285260 )	Alanine aminotransferase levels ( 33547301 ) Body mass index ( 28552196 )
Novel Interactors		3 novel interactors: CDON EI24 PLEKHB2	2 novel interactors: KCNJ1 NRGN
Interacting Genes		6 interacting genes: CALM1 EIF5 GLP1R PRKCA PRKCB PRKCG	6 interacting genes: BNIP2 CCR8 PGRMC2 RABAC1 TMED8 TMEM14B
Entrez ID		4900	9538
HPRD ID		03828	05526
Ensembl ID		ENSG00000154146	ENSG00000149547
Uniprot IDs		Q92686	E9PK61 O14681
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Presynaptic Cytosol Protein Kinase C Signaling Response To Psychosocial Stress Mitotic Nuclear Membrane Disassembly Nuclear Membrane Disassembly Membrane Disassembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Exocytosis Presynaptic Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Learning Or Memory Nuclear Membrane Organization Regulation Of Synaptic Vesicle Exocytosis Long-term Synaptic Potentiation G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Cognition Glucagon-like Peptide 1 Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Nervous System Process Positive Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Serine/threonine Kinase Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Protein Transport Response To Toxic Substance Signal Transduction Negative Regulation Of Transmembrane Transport Eukaryotic Initiation Factor EIF2 Binding Glucagon Receptor Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Mismatch Repair Regulation Of Intracellular Signal Transduction Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Intracellular Signal Transduction	None