TMEM59 and ATG16L1

Number of citations of the paper that reports this interaction (PMID 23376921)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TMEM59	ATG16L1
Gene Name		transmembrane protein 59	autophagy related 16-like 1 (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Cis Cisterna Golgi Trans Cisterna Golgi Membrane Lysosome Lysosomal Membrane Late Endosome Golgi Medial Cisterna Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Autophagic Vacuole Membrane Autophagic Vacuole Axoneme Pre-autophagosomal Structure Membrane
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Glycosylation In Golgi	Autophagic Vacuole Assembly Protein Transport Negative Stranded Viral RNA Replication Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 23128233)
Protein-Protein Interactions		1 interactors: ATG16L1	6 interactors: APP ATG5 RAB33A RAB33B TMEM59 UBC
Entrez ID		9528	55054
HPRD ID		12731	16498
Ensembl ID		ENSG00000116209	ENSG00000085978
Uniprot IDs		D3DQ48 Q9BXS4	E7EVC7 Q17RG0 Q53SV2 Q676U5
PDB IDs			4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Negative Stranded Viral RNA Replication Viral Genome Replication Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Cellular Response To Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Viral Life Cycle Cellular Response To Extracellular Stimulus Protein Homooligomerization	Regulation Of Autophagy Regulation Of Autophagic Vacuole Assembly Autophagy Regulation Of Vacuole Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Rab Protein Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Transport Negative Regulation Of Constitutive Secretory Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Type I Interferon Production Catabolic Process Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Glycosylation In Golgi Notch Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Innate Immune Response Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Viral Life Cycle Negative Regulation Of Protein Glycosylation Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Localization Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Localization Cell Death Death Otolith Development Axon Choice Point Recognition
Tagcloud ?		agtpbp1 atic calb1 cct4 copa fabp7 h2afy hierarchical ids milieu neurofibrillary omnibus organized prdx3 rnf14 sap18 senile sfpq smarcb1 sorl1 ssbp1 stxbp3 syncrip syne2 tangles treeview txnl4a ulk2 visualized	1alpha 20a atg12 atg5 atg7 atg9a atgs autophagic autophagy becn1 cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Difference) ?		agtpbp1 atic calb1 cct4 copa fabp7 h2afy hierarchical ids milieu neurofibrillary omnibus organized prdx3 rnf14 sap18 senile sfpq smarcb1 sorl1 ssbp1 stxbp3 syncrip syne2 tangles treeview txnl4a ulk2 visualized	1alpha 20a atg12 atg5 atg7 atg9a atgs autophagic autophagy becn1 cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Intersection) ?