PMPCB and ZNHIT1

		PMPCB	ZNHIT1
Description		peptidase, mitochondrial processing subunit beta	zinc finger HIT-type containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Processing Peptidase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Heart Process Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of T Cell Proliferation Muscle Cell Differentiation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Transcription Initiation-coupled Chromatin Remodeling Calcium Ion Homeostasis Positive Regulation Of Transcription Initiation By RNA Polymerase II Hematopoietic Stem Cell Homeostasis Negative Regulation Of G0 To G1 Transition Positive Regulation Of Lymphoid Progenitor Cell Differentiation
Pathways		Mitochondrial protein import Processing of SMDT1
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		5 interacting genes: FXN MARK3 NPSR1 PMPCA PTGER4	23 interacting genes: APP BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53
Entrez ID		9512	10467
HPRD ID		07539	15892
Ensembl ID		ENSG00000105819	ENSG00000106400
Uniprot IDs		A0A9L9PXG6 A0A9L9PXH0 A0A9L9PXI7 B3KM34 G3V0E4 O75439 Q96CP5	O43257
PDB IDs			8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Reactive Oxygen Species Metabolic Process MAP Kinase Activity Cellular Senescence Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Cell Cycle Process Stress-induced Premature Senescence NLRP1 Inflammasome Complex Assembly Positive Regulation Of Apoptotic Signaling Pathway Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cytokine Production Identical Protein Binding Inflammatory Response Negative Regulation Of Cell Cycle Cellular Response To UV-B Regulation Of MiRNA Processing Intracellular Signaling Cassette Necroptotic Process Regulation Of Regulatory NcRNA Processing Cellular Response To Oxygen-containing Compound Protein Serine/threonine Kinase Activity Cellular Response To UV Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition MAPK Cascade DNA Damage Checkpoint Signaling Programmed Necrotic Cell Death Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cell Population Proliferation Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA Replication Cellular Response To Light Stimulus P38MAPK Cascade Response To UV-B Stress-activated MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing
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