FHL5 and FHL3

Number of citations of the paper that reports this interaction (PMID 11046156)
37

Data Source:
BioGRID (two hybrid)

		FHL5	FHL3
Gene Name		four and a half LIM domains 5	four and a half LIM domains 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding	Actin Binding Zinc Ion Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter	Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Coronary heart disease ( 22319020) Migraine ( 22683712)
Protein-Protein Interactions		12 interactors: COIL CREB1 CREM DNAL4 FHL2 FHL3 HOXA1 KIF17 SMAD1 SRF STX11 ZNF446	88 interactors: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP C14orf105 C9orf116 CDC25B CDC42EP1 CNNM3 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EPHA10 EPM2AIP1 FAM154A FAM71C FAM90A1 FBXL18 FHL2 FHL5 FOSL2 GATA2 GCM2 HIPK1 HYAL2 ITGA7 KIRREL2 KLF3 KLF8 KRTAP12-1 KRTAP12-2 KTI12 LASP1 LMO2 LNX1 MAPK1 MED15 MPZL1 MRPL27 MYBPC1 MYBPHL MZF1 NPRL3 P4HA2 PAK7 PATL1 PHC2 PHF21A PLEKHF2 PPIG PTPN6 QRICH1 RAD21 RBM42 RFX3 RFX6 RHEBL1 RNMTL1 SAP30BP SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SREBF2 SRF TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 WNK1 YPEL3 ZNF417 ZNF512B ZNRD1
Entrez ID		9457	2275
HPRD ID		05497	09101
Ensembl ID		ENSG00000112214	ENSG00000183386
Uniprot IDs		Q5TD97	Q13643 Q96C98
PDB IDs		1X68	1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Heart Trabecula Formation RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Trabecula Morphogenesis Cardiac Muscle Tissue Development RNA Metabolic Process Tube Development Trabecula Morphogenesis Multicellular Organismal Development Cell Differentiation Gene Expression Cognition Brain Development Artery Morphogenesis Striated Muscle Tissue Development Cellular Macromolecule Biosynthetic Process Head Development Macromolecule Biosynthetic Process Muscle Tissue Development Artery Development Positive Regulation Of Cellular Metabolic Process Cardiac Muscle Cell Development Cardiovascular System Development Transcription From RNA Polymerase II Promoter Abducens Nerve Formation Contractile Actin Filament Bundle Assembly Optokinetic Behavior Neurogenesis Developmental Process Mesoderm Formation Central Nervous System Development Mesoderm Morphogenesis System Development Cellular Response To Organic Substance Facial Nucleus Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Single-organism Behavior Organ Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process Cardiac Muscle Cell Differentiation	RNA Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Cell Death Death Multicellular Organismal Homeostasis Positive Regulation Of Epithelial To Mesenchymal Transition Endoderm Development Negative Regulation Of Cell Growth Embryonic Organ Development Positive Regulation Of Metabolic Process Primary MiRNA Processing Organ Development Apoptotic Process
Tagcloud ?		1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp atp5b c7orf10 candidate fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1
Tagcloud (Difference) ?		1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp atp5b c7orf10 candidate fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1
Tagcloud (Intersection) ?