GGPS1 and ATOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GGPS1	ATOX1
Description		geranylgeranyl diphosphate synthase 1	antioxidant 1 copper chaperone
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Z Disc Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Dimethylallyltranstransferase Activity Geranylgeranyl Diphosphate Synthase Activity (2E,6E)-farnesyl Diphosphate Synthase Activity Prenyltransferase Activity Protein Binding Transferase Activity Identical Protein Binding Metal Ion Binding Prenyl Diphosphate Synthase Activity	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding
	Biological Process	Lipid Metabolic Process Isoprenoid Metabolic Process Isoprenoid Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		Pamidronic acid Zoledronic acid Ibandronate Geranyl Diphosphate Farnesyl thiopyrophosphate ISOPENTENYL PYROPHOSPHATE Minodronic acid (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate Lauryl alcohol diphosphonic acid (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)	Cisplatin Sucrose Benzamidine
Diseases
GWAS		Asthma ( 29273806)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		2 interacting genes: ATOX1 SDCBP	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		9453	475
HPRD ID		06099	03779
Ensembl ID		ENSG00000152904	ENSG00000177556
Uniprot IDs		O95749	O00244
PDB IDs		2Q80 6C56 6C57 6G31 6G32 6R4V 9CSL	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3
Enriched GO Terms of Interacting Partners?		Copper-dependent Protein Binding Copper Ion Export Copper Chaperone Activity Metallochaperone Activity Nuclear Membrane Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Extracellular Exosome Assembly Copper Ion Transmembrane Transport Interleukin-27-mediated Signaling Pathway Cuprous Ion Binding Substrate-dependent Cell Migration, Cell Extension Response To Type I Interferon Intracellular Copper Ion Homeostasis Copper Ion Transport Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Copper Ion Homeostasis Regulation Of Exosomal Secretion Cytoskeletal Anchor Activity	Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?