GSTO1 and SERPINB5

Number of citations of the paper that reports this interaction (PubMedID 16049007)
0

Data Source:
BioGRID (two hybrid)

		GSTO1	SERPINB5
Description		glutathione S-transferase omega 1	serpin family B member 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Sarcoplasm
	Molecular Function	Glutathione Transferase Activity Protein Binding Oxidoreductase Activity Transferase Activity Glutathione Dehydrogenase (ascorbate) Activity Methylarsonate Reductase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion L-ascorbic Acid Metabolic Process Xenobiotic Catabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Arsenic-containing Substance Cellular Oxidant Detoxification	Morphogenesis Of An Epithelium Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways		Methylation Glutathione conjugation Vitamin C (ascorbate) metabolism Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Glutathione	S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		10 interacting genes: APP CEP126 CFTR EEF1G FILNC1 HSPB1 KAT5 RBM48 SERPINB5 SETDB1	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF PTBP1 SMAD4 TBP TKT UCHL5 XRCC3
Entrez ID		9446	5268
HPRD ID		10401	01111
Ensembl ID		ENSG00000148834	ENSG00000206075
Uniprot IDs		P78417 V9HWG9	P36952
PDB IDs		1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV 5UEH 5V3Q 5YVN 5YVO 6MHB 6MHC 6MHD 6PNM 6PNN 6PNO	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Microtubule-based Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Interleukin-1 Beta Production Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Cornified Envelope Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Interleukin-1 Production Cellular Response To Norepinephrine Stimulus Chromatin Binding Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Enamel Mineralization	Nitric-oxide Synthase Regulator Activity Protein-containing Complex Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasm Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Kinase Binding Regulation Of Protein Catabolic Process Cytosol Extracellular Exosome TFIIB-class Transcription Factor Binding Telomere Maintenance COP9 Signalosome ATP-dependent Protein Folding Chaperone Animal Organ Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Apoptotic Process Telomerase Holoenzyme Complex Assembly Telomere Organization Protein Homodimerization Activity Positive Regulation Of Signal Transduction Brainstem Development Transcription Corepressor Binding Dendritic Growth Cone TPR Domain Binding Regulation Of Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Negative Regulation Of Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Maintenance Of Protein Localization In Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Developmental Process Negative Regulation Of Muscle Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Striated Muscle Contraction Regulation Of Protein Ubiquitination Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Regulation Of Growth Positive Regulation Of Cell Differentiation
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