TMEM203 and CD3G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM203	CD3G
Description		transmembrane protein 203	CD3 gamma subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Spermatogenesis	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Muromonab Teclistamab Odronextamab
Diseases
GWAS
Interacting Genes		41 interacting genes: ANK1 AQP6 ATP6AP2 CD3G CNR2 CPLX4 CREB3 CREB3L1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 GPX8 HSD17B11 HSD17B13 KCNJ6 LMNA LY6G6C MANBAL MMD PDZK1IP1 RETREG3 RMDN3 RNASEK SCN3B SLC10A6 SLC18A1 SLC61A1 SSMEM1 STOM STX4 TIMMDC1 TMEM14B TMEM234 TMEM31 TMEM52B TMEM60 TMEM86B TMX2	14 interacting genes: CATSPERH CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD
Entrez ID		94107	917
HPRD ID		17496	07037
Ensembl ID		ENSG00000187713	ENSG00000160654
Uniprot IDs		Q969S6	B0YIY5 P09693
PDB IDs			1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Steroid Dehydrogenase Activity Protein Binding Endoplasmic Reticulum Membrane Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin
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