ORMDL3 and C10orf67

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ORMDL3	C10orf67
Description		ORMDL sphingolipid biosynthesis regulator 3	chromosome 10 open reading frame 67
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Serine Palmitoyltransferase Complex Secretory Granule Membrane Specific Granule Membrane	Mitochondrion
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 17611496 29273806 31959851 28461288 22561531 21150878 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908 18587394) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 25751624 30659077 21829393 19430480) Ulcerative colitis ( 28067908 21297633 20228799) White blood cell count ( 27863252 21738480)	Crohn's disease and sarcoidosis (combined) ( 18723019) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 19838195)
Interacting Genes		30 interacting genes: APP AQP6 ARL13B C10orf67 CERS3 COQ8A EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 LEPROTL1 LMNA LNX1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35H1 SLC7A1 SYT2 TMEM237	13 interacting genes: ACSF2 ALOX5 BCL2L1 BCL2L2 NOD2 ORMDL3 SEC22A SYT16 TMED8 TMEM14B TMEM19 TMEM208 TNF
Entrez ID		94103	256815
HPRD ID		17803	12585
Ensembl ID		ENSG00000172057	ENSG00000179133
Uniprot IDs		Q8N138	A0A6E2AE84 Q8IYJ2
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Membrane	Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Negative Regulation Of Vascular Wound Healing Negative Regulation Of Leukocyte Apoptotic Process Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Vascular Wound Healing Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Release Of Cytochrome C From Mitochondria Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Epithelial Cell Proliferation Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process In Bone Marrow Cell Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Negative Regulation Of Endothelial Cell Proliferation Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Wound Healing Arachidonate 8(S)-lipoxygenase Activity Apoptotic Mitochondrial Changes Cellular Response To Ionizing Radiation Positive Regulation Of Interleukin-1 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Interleukin-8 Production Positive Regulation Of Fractalkine Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
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