ORMDL3 and CRHR1

		ORMDL3	CRHR1
Description		ORMDL sphingolipid biosynthesis regulator 3	corticotropin releasing hormone receptor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Serine Palmitoyltransferase Complex Secretory Granule Membrane Specific Granule Membrane	Endosome Plasma Membrane Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Ceramide Biosynthetic Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Adrenal Gland Development Cellular Response To Hormone Stimulus Exploration Behavior Fear Response Behavioral Response To Ethanol Regulation Of Transport Corticotropin Secretion General Adaptation Syndrome, Behavioral Process Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			Corticorelin ovine triflutate
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 17611496 29273806 31959851 28461288 22561531 21150878 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908 18587394) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 25751624 30659077 21829393 19430480) Ulcerative colitis ( 28067908 21297633 20228799) White blood cell count ( 27863252 21738480)	A body shape index ( 34021172) Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Brain morphology (MOSTest) ( 32665545) Cerebral white matter volume ( 31530798) Cortical surface area (global PC1) ( 32198502) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Reticulocyte count ( 32888494) Schizophrenia ( 33169155) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: APP AQP6 ARL13B C10orf67 CERS3 COQ8A EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 LEPROTL1 LMNA LNX1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35H1 SLC7A1 SYT2 TMEM237	20 interacting genes: ARRB1 ARRB2 CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ PDZK1 PTPN13 SRPK1 UCN UCN3
Entrez ID		94103	1394
HPRD ID		17803	08830
Ensembl ID		ENSG00000172057	ENSG00000120088
Uniprot IDs		Q8N138	B3SXS2 B3TIK8 G3CIS4 K9J956 P34998
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2	2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G 6P9X 6PB0 8GTG 8GTI 8GTM
Enriched GO Terms of Interacting Partners?		Membrane	Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of System Process Regulation Of Transport Regulation Of Muscle System Process Guanyl Nucleotide Binding Corticotropin-releasing Hormone Receptor 2 Binding Adenylate Cyclase Regulator Activity G-protein Beta/gamma-subunit Complex Binding Plasma Membrane G Protein-coupled Receptor Binding D1 Dopamine Receptor Binding Heterotrimeric G-protein Complex Varicosity Regulation Of Peptide Hormone Secretion Bicellular Tight Junction Negative Regulation Of Transport Regulation Of Protein Localization Regulation Of Hormone Secretion Signal Transduction Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Mu-type Opioid Receptor Binding G Protein Activity Regulation Of Insulin Secretion Regulation Of Muscle Contraction Regulation Of Receptor Internalization G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Transport Beta-1 Adrenergic Receptor Binding G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Response To Prostaglandin E Positive Regulation Of Receptor Internalization Response To Ketone Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Ionotropic Glutamate Receptor Binding Cell Projection Regulation Of Monoatomic Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Postsynaptic Density Response To Alcohol Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase Activator Activity Regulation Of Protein Secretion Dendrite Desensitization Of G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission
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