SEP15 and BAMBI

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SEP15	BAMBI
Gene Name		15 kDa selenoprotein	BMP and activin membrane-bound inhibitor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Selenium Binding	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding
	Biological Process	'de Novo' Posttranslational Protein Folding	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Preeclampsia ( 23551011)
Protein-Protein Interactions		4 interactors: BAMBI UGGT1 UGGT2 XRCC6	8 interactors: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B SEP15 SOX30 TGFBR1
Entrez ID		9403	25805
HPRD ID		09376	05117
Ensembl ID		ENSG00000183291	ENSG00000095739
Uniprot IDs		O60613	Q13145
PDB IDs
Enriched GO Terms of Interacting Partners?		UDP-glucosylation UDP-glucose Metabolic Process Nucleotide-sugar Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Post-translational Protein Modification Cellular Hyperosmotic Salinity Response Protein Folding Cellular Response To X-ray Macromolecule Glycosylation Protein Glycosylation Glycosylation Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Glycoprotein Biosynthetic Process Positive Regulation Of Catenin Import Into Nucleus Cellular Response To Salt Stress Glycoprotein Metabolic Process DNA Ligation Positive Regulation Of Cell Development Nucleotide Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Catenin Import Into Nucleus Hyperosmotic Response Nucleobase-containing Small Molecule Metabolic Process V(D)J Recombination Cellular Response To Osmotic Stress Response To X-ray Positive Regulation Of Epithelial To Mesenchymal Transition Response To Salt Stress Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Differentiation Peptidyl-amino Acid Modification Regulation Of Epithelial To Mesenchymal Transition 'de Novo' Posttranslational Protein Folding Cellular Response To Ionizing Radiation 'de Novo' Protein Folding Organophosphate Metabolic Process Carbohydrate Metabolic Process Positive Regulation Of Protein Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Telomere Maintenance DNA Duplex Unwinding Macromolecule Biosynthetic Process DNA Geometric Change Positive Regulation Of Type I Interferon Production	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus In Utero Embryonic Development Response To Transforming Growth Factor Beta Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Peptidyl-threonine Phosphorylation Positive Regulation Of Signal Transduction Protein Phosphorylation Reproductive Process Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Sex Differentiation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Tissue Development Positive Regulation Of Ossification Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Mesenchymal Cell Development Pathway-restricted SMAD Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Protein Phosphorylation Mesenchymal Cell Differentiation Pattern Specification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Pharyngeal System Development Embryo Development Positive Regulation Of Epithelial Cell Proliferation Single Organism Reproductive Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Activin Receptor Signaling Pathway
Tagcloud ?			95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998
Tagcloud (Difference) ?			95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998
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