BAMBI

Gene Name		BMP and activin membrane-bound inhibitor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Preeclampsia ( 23551011)
Protein-protein Interactions		8 interactors: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B SEP15 SOX30 TGFBR1
Entrez ID		25805
HPRD ID		05117
Ensembl ID		ENSG00000095739
Uniprot IDs		Q13145
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus In Utero Embryonic Development Response To Transforming Growth Factor Beta Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Peptidyl-threonine Phosphorylation Positive Regulation Of Signal Transduction Protein Phosphorylation Reproductive Process Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Sex Differentiation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Tissue Development Positive Regulation Of Ossification Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Mesenchymal Cell Development Pathway-restricted SMAD Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Protein Phosphorylation Mesenchymal Cell Differentiation Pattern Specification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Pharyngeal System Development Embryo Development Positive Regulation Of Epithelial Cell Proliferation Single Organism Reproductive Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Activin Receptor Signaling Pathway
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