TAOK2 and SETD1A

		TAOK2	SETD1A
Description		TAO kinase 2	SET domain containing 1A, histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Protein Binding Beta-catenin Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Focal Adhesion Assembly Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization	Chromatin Organization Chromatin Remodeling DNA Damage Response Brain Development Methylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes
Drugs		Dexfosfoserine Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 30285260 29483656 28991256 25056061) Triglyceride levels ( 32154731 32203549) Waist circumference ( 31928498)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Red blood cell count ( 32888494)
Interacting Genes		12 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1	5 interacting genes: DPY30 EP300 H3C1 H3C14 LBP
Entrez ID		9344	9739
HPRD ID		18147	13795
Ensembl ID		ENSG00000149930	ENSG00000099381
Uniprot IDs		Q9UL54	O15047
PDB IDs			3S8S 3UVN 4EWR 8ILY
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus NLRP1 Inflammasome Complex Assembly Response To Radiation Cellular Response To UV-B MAP Kinase Kinase Activity COPII Vesicle Coat Structural Constituent Of Cytoskeleton Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade	Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Tau Protein Binding Chromatin Organization Epigenetic Regulation Of Gene Expression Peptidyl-lysine Propionylation Swimming Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Histone Crotonyltransferase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Structural Constituent Of Chromatin Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Regulation Of Glucose Metabolic Process Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Nucleosome Assembly N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Nucleosome Nucleosome Organization Basal Dendrite Morphogenesis Basal Dendrite Arborization Negative Regulation Of Protein Oligomerization Catalytic Activity, Acting On A Protein Chromosome Isoleucine Metabolic Process L-isoleucine Catabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity L-valine Catabolic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Innate Immune Response-activating Signaling Pathway Lipoteichoic Acid Binding Protein-DNA Complex Assembly Valine Metabolic Process L-leucine Catabolic Process Positive Regulation Of TORC2 Signaling
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