IGSF8 and SLIT3

		IGSF8	SLIT3
Description		immunoglobulin superfamily member 8	slit guidance ligand 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse	Extracellular Region Extracellular Space Mitochondrion
	Molecular Function	Protein Binding Signaling Receptor Activity	Calcium Ion Binding Heparin Binding Roundabout Binding
	Biological Process	Single Fertilization Nervous System Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Nervous System Development Axon Guidance Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Differentiation Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways			Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 25429064 20881960 31562340 25282103) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)
Interacting Genes		18 interacting genes: A2M CD81 CD82 CD9 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 NBPF19 NOTCH2NLA TGM1	2 interacting genes: CAPN1 ROBO2
Entrez ID		93185	6586
HPRD ID		09438	04775
Ensembl ID		ENSG00000162729	ENSG00000184347
Uniprot IDs		Q969P0	O75094
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Myoblast Fusion Involved In Skeletal Muscle Regeneration Cellular Response To Lipoprotein Particle Stimulus Myoblast Fusion Regulation Of Mononuclear Cell Migration Cell-cell Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Macrophage Migration
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