HNRNPLL and PRSS8

		HNRNPLL	PRSS8
Description		heterogeneous nuclear ribonucleoprotein L like	serine protease 8
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GO Annotations	Cellular Component	Nucleus Membrane Synapse Ribonucleoprotein Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	MRNA Processing Positive Regulation Of RNA Splicing Regulation Of RNA Splicing	Proteolysis Positive Regulation Of Sodium Ion Transport
Pathways			Formation of the cornified envelope
Drugs			1-[4-(hydroxymethyl)phenyl]guanidine
Diseases
GWAS		Body mass index ( 28892062)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		57 interacting genes: ADAMTSL4 ATXN1 BANP BARD1 BCAS2 BHLHE40 BOLL CALCOCO2 CEBPA DAB1 DDX39A DDX39B DENND2D EFHC2 EIF4ENIF1 FAM9B GOPC HNRNPK HOOK1 IKZF3 KHDRBS2 KRT31 KRT40 KRTAP10-3 MAGED1 MDFI MID2 MREG PAXIP1 PCBP1 PCBP3 PNMA1 POLR1F PRPF6 PTBP1 QKI RBM10 RBM3 RBPMS REL RHOXF2 SKIL SNRPA SPRY2 SRSF11 SSX2IP SUMO2 TADA2A THAP1 TLE5 TMCC2 TRIM23 TRIM27 UBE2I USP10 VAC14 WEE2-AS1	2 interacting genes: ATF7IP SLC13A1
Entrez ID		92906	5652
HPRD ID		13667	02895
Ensembl ID		ENSG00000143889	ENSG00000052344
Uniprot IDs		A0A0S2Z6K1 A8K894 Q8WVV9	Q16651
PDB IDs		7EVS	3DFJ 3DFL 3E0N 3E0P 3E16 3E1X 3FVF 3GYL 3GYM
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Identical Protein Binding RNA Binding Regulation Of MRNA Processing MRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Processing RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body MRNA Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Nuclear Speck RNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Nucleic Acid Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process MRNA Stabilization Nuclear Export Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process	Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Secondary Active Sulfate Transmembrane Transporter Activity
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