HNRNPLL and OTOF

		HNRNPLL	OTOF
Description		heterogeneous nuclear ribonucleoprotein L like	otoferlin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Membrane Synapse Ribonucleoprotein Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Calcium Ion Binding Metal Ion Binding
	Biological Process	MRNA Processing Positive Regulation Of RNA Splicing Regulation Of RNA Splicing	Sensory Perception Of Sound Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Membrane Fusion
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases			Deafness, autosomal recessive
GWAS		Body mass index ( 28892062)	Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Periodontal microbiota ( 22699663)
Interacting Genes		57 interacting genes: ADAMTSL4 ATXN1 BANP BARD1 BCAS2 BHLHE40 BOLL CALCOCO2 CEBPA DAB1 DDX39A DDX39B DENND2D EFHC2 EIF4ENIF1 FAM9B GOPC HNRNPK HOOK1 IKZF3 KHDRBS2 KRT31 KRT40 KRTAP10-3 MAGED1 MDFI MID2 MREG PAXIP1 PCBP1 PCBP3 PNMA1 POLR1F PRPF6 PTBP1 QKI RBM10 RBM3 RBPMS REL RHOXF2 SKIL SNRPA SPRY2 SRSF11 SSX2IP SUMO2 TADA2A THAP1 TLE5 TMCC2 TRIM23 TRIM27 UBE2I USP10 VAC14 WEE2-AS1	4 interacting genes: BTG3 SRPK2 STK39 USP7
Entrez ID		92906	9381
HPRD ID		13667	04727
Ensembl ID		ENSG00000143889	ENSG00000115155
Uniprot IDs		A0A0S2Z6K1 A8K894 Q8WVV9	Q9HC10
PDB IDs		7EVS
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Identical Protein Binding RNA Binding Regulation Of MRNA Processing MRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Processing RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body MRNA Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Nuclear Speck RNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Nucleic Acid Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process MRNA Stabilization Nuclear Export Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process	Peptidyl-serine Phosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Regulation Of RNA Splicing Phosphorylation Protein Serine Kinase Activity Nuclear Body Organization Protein Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck Organization Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination Negative Regulation Of Gluconeogenesis Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair K48-linked Deubiquitinase Activity Maintenance Of Lens Transparency Chloride Ion Homeostasis Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Positive Regulation Of Lymphocyte Chemotaxis Hypotonic Response Cellular Hyperosmotic Response Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Transporter Activator Activity Ion Channel Regulator Activity Cellular Response To Potassium Ion Transporter Inhibitor Activity Cellular Hypotonic Response Cellular Response To Chemokine Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transport Potassium Channel Inhibitor Activity Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Regulation Of Potassium Ion Import Negative Regulation Of Sodium Ion Transmembrane Transport Response To Dietary Excess Response To Aldosterone MRNA Processing Response To Potassium Ion Monoatomic Anion Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Peptidyl-threonine Phosphorylation
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