DDX21 and ADAMTS14

		DDX21	ADAMTS14
Description		DExD-box helicase 21	ADAM metallopeptidase with thrombospondin type 1 motif 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane B-WICH Complex	Extracellular Region Extracellular Matrix
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding RNA Polymerase Inhibitor Activity	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Chromatin Remodeling RRNA Processing Transcription By RNA Polymerase II Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Defense Response To Virus R-loop Processing	Proteolysis Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Moderate-to-late spontaneous preterm birth ( 31194736) Optic disc size ( 31809533) Sleep duration ( 23728906) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Suicide behavior ( 26079190)
Interacting Genes		88 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN RBFOX2 RPL34 SUMO2 TERF1 TERF2 UBE2I USP7
Entrez ID		9188	140766
HPRD ID		05895	06329
Ensembl ID		ENSG00000165732	ENSG00000138316
Uniprot IDs		A0A8I5KYZ4 Q9NR30	Q8WXS8
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling	B-WICH Complex RNA Polymerase Inhibitor Activity 7SK SnRNA Binding Negative Regulation Of Transcription By RNA Polymerase I R-loop Processing Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Dendritic Cell Cytokine Production SnoRNA Binding Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase I MiRNA Binding Response To Exogenous DsRNA Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Response To DsRNA Regulation Of Transcription By RNA Polymerase I RRNA Binding Double-stranded RNA Binding RNA Helicase Activity Positive Regulation Of Cytokine Production Involved In Immune Response Osteoblast Differentiation Helicase Activity Regulation Of Cytokine Production Involved In Immune Response
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