ADAMTS14

Description		ADAM metallopeptidase with thrombospondin type 1 motif 14
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Moderate-to-late spontaneous preterm birth ( 31194736) Optic disc size ( 31809533) Sleep duration ( 23728906) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Suicide behavior ( 26079190)
Novel Interacting Genes		1 novel interacting genes: DDX21
Interacting Genes
Entrez ID		140766
HPRD ID		06329
Ensembl ID		ENSG00000138316
Uniprot IDs		Q8WXS8
PDB IDs
Enriched GO Terms of Interacting Partners?		B-WICH Complex RNA Polymerase Inhibitor Activity 7SK SnRNA Binding Negative Regulation Of Transcription By RNA Polymerase I R-loop Processing Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Dendritic Cell Cytokine Production SnoRNA Binding Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase I MiRNA Binding Response To Exogenous DsRNA Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Response To DsRNA Regulation Of Transcription By RNA Polymerase I RRNA Binding Double-stranded RNA Binding RNA Helicase Activity Positive Regulation Of Cytokine Production Involved In Immune Response Osteoblast Differentiation Helicase Activity Regulation Of Cytokine Production Involved In Immune Response
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