LIN52 and NEK9

		LIN52	NEK9
Description		lin-52 DREAM MuvB core complex component	NIMA related kinase 9
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GO Annotations	Cellular Component	Nucleoplasm DRM Complex	Nucleus Cytoplasm Centrosome Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		4 interacting genes: DYRK1A EPM2AIP1 MAGEA6 RBL2	16 interacting genes: BICD2 CSN2 GABARAP MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PELI2 RAN SSRP1 SUPT16H TTN UBC WEE2-AS1
Entrez ID		91750	91754
HPRD ID		18708	11386
Ensembl ID		ENSG00000205659	ENSG00000119638
Uniprot IDs		B3KN83 Q52LA3	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		4YOO 6C48	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Histone H3T45 Kinase Activity	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization
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