P2RX6 and CDH5

Number of citations of the paper that reports this interaction (PubMedID 12088286)
0

Data Source:
HPRD (in vivo)

		P2RX6	CDH5
Description		purinergic receptor P2X 6	cadherin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Junction Neuronal Cell Body Dendritic Spine Receptor Complex Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Postsynaptic Specialization Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Catenin Complex Cell Junction Nuclear Membrane Anchoring Junction Cell Periphery
	Molecular Function	Purinergic Nucleotide Receptor Activity Transmembrane Signaling Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Channel Activity Protein-containing Complex Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Signaling Receptor Complex Adaptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Metal Ion Binding Fibrinogen Binding BMP Receptor Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding
	Biological Process	Monoatomic Ion Transport Muscle Contraction Signal Transduction Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport	Cell Morphogenesis Endothelial Cell Morphogenesis Blood Vessel Maturation Cell Migration Involved In Sprouting Angiogenesis Intracellular Calcium Ion Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	Adherens junctions interactions VEGFR2 mediated vascular permeability High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Promethazine	Lenalidomide FX06
Diseases
GWAS			Body size at age 10 ( 32376654) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		2 interacting genes: APP CDH5	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		9127	1003
HPRD ID		08490	03075
Ensembl ID		ENSG00000099957	ENSG00000179776
Uniprot IDs		O15547	P33151 Q59EA3
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Signaling Receptor Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Intracellular Monoatomic Cation Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Developmental Maturation Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis External Side Of Plasma Membrane Regulation Of Supramolecular Fiber Organization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Inflammatory Response Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Junction Organization Monoatomic Ion Homeostasis Axon Choice Point Recognition Monoatomic Cation Homeostasis Blood Vessel Maturation Fibrinogen Binding Heparan Sulfate Binding Signaling Receptor Activator Activity Intracellular Chemical Homeostasis	Cadherin Binding Cell Adhesion Anchoring Junction Cell Junction Catenin Complex Cell-cell Junction Organization Cell-cell Adhesion Cellular Response To Indole-3-methanol Response To Indole-3-methanol Regulation Of Protein Localization Adherens Junction Cell-cell Junction Plasma Membrane Cell Junction Organization Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Positive Regulation Of Protein Localization Adherens Junction Organization Cell Motility Cell-cell Junction Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Localization Desmosome ERBB Signaling Pathway Cell Junction Assembly Regulation Of Cell Adhesion Regulation Of Transport Flotillin Complex Cell Adhesion Molecule Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Regulation Of MAPK Cascade Intercalated Disc Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Desmosome Organization Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Shc-EGFR Complex Epithelial Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Cellular Response To Growth Factor Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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