P2RX6 and CDH5

Number of citations of the paper that reports this interaction (PMID 12088286)
8

Data Source:
HPRD (in vivo)

		P2RX6	CDH5
Gene Name		purinergic receptor P2X, ligand gated ion channel, 6	cadherin 5, type 2 (vascular endothelium)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Cytoplasm Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Neuronal Cell Body Dendritic Spine	Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	Purinergic Nucleotide Receptor Activity Transmembrane Signaling Receptor Activity Extracellular ATP-gated Cation Channel Activity ATP Binding Channel Activity Identical Protein Binding	Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Ion Channel Binding
	Biological Process	Transport Cation Transport Muscle Contraction Signal Transduction Purinergic Nucleotide Receptor Signaling Pathway Protein Homooligomerization Protein Heterooligomerization Transmembrane Transport Cation Transmembrane Transport	Blood Vessel Maturation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Proliferation Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways			Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP CDH5	20 interactors: CSK CTNNA1 CTNNB1 CTNND1 DSP EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		9127	1003
HPRD ID		08490	03075
Ensembl ID			ENSG00000179776
Uniprot IDs		O15547	P33151
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Blood Vessel Maturation Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion Mating Behavior Regulation Of Establishment Of Cell Polarity Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition Regulation Of Establishment Or Maintenance Of Cell Polarity RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Component Assembly Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Adherens Junction Organization Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth	Cell-cell Junction Organization Adherens Junction Organization Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Indole-3-methanol Cell Junction Assembly Regulation Of ERK1 And ERK2 Cascade Cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Response To Stimulus Regulation Of Signal Transduction Response To Wounding Positive Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Cell Migration Cell Motility Wound Healing Response To Growth Factor Regulation Of Intracellular Signal Transduction Platelet Activation Organ Development Cellular Response To Organic Substance Cellular Component Assembly Cell Activation Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Organic Substance Movement Of Cell Or Subcellular Component Cell-cell Junction Assembly Protein Heterooligomerization Negative Regulation Of Signaling Regulation Of Protein Localization System Development Peptidyl-tyrosine Phosphorylation Response To Stress Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation
Tagcloud ?			1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?			1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?