P2RX6

Description		purinergic receptor P2X 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Junction Neuronal Cell Body Dendritic Spine Receptor Complex Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Purinergic Nucleotide Receptor Activity Transmembrane Signaling Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Channel Activity Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Muscle Contraction Signal Transduction Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine
Diseases
GWAS
Interacting Genes		2 interacting genes: APP CDH5
Entrez ID		9127
HPRD ID		08490
Ensembl ID		ENSG00000099957
Uniprot IDs		O15547
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Signaling Receptor Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Intracellular Monoatomic Cation Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Developmental Maturation Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis External Side Of Plasma Membrane Regulation Of Supramolecular Fiber Organization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Inflammatory Response Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Junction Organization Monoatomic Ion Homeostasis Axon Choice Point Recognition Monoatomic Cation Homeostasis Blood Vessel Maturation Fibrinogen Binding Heparan Sulfate Binding Signaling Receptor Activator Activity Intracellular Chemical Homeostasis
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