ZNF396 and SPSB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF396	SPSB3
Description		zinc finger protein 396	splA/ryanodine receptor domain and SOCS box containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Cytosol SCF Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways			Neddylation
Drugs
Diseases
GWAS		Parasitemia in Tripanosoma cruzi seropositivity ( 24324551) Parkinson's disease ( 26227905)	Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)
Interacting Genes		8 interacting genes: CDKN2D NFE2L2 PROSER3 SPSB3 ZNF397 ZSCAN1 ZSCAN21 ZSCAN32	6 interacting genes: CFTR CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396
Entrez ID		252884	90864
HPRD ID		18334	18107
Ensembl ID		ENSG00000186496	ENSG00000162032
Uniprot IDs		Q96N95	Q6PJ21
PDB IDs			8OKX 8OL1
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Positive Regulation Of Anion Channel Activity Anatomical Structure Morphogenesis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Neuroblast Division In Subventricular Zone Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Release From Viral Latency Adiponectin-activated Signaling Pathway Signal Complex Assembly Nonassociative Learning Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Neuron Projection Morphogenesis Cell Projection Morphogenesis JUN Kinase Binding 9+0 Non-motile Cilium Regulation Of Monoatomic Anion Transport Cytoplasm Epithelial Fluid Transport Endothelial Tube Morphogenesis Cell Projection Organization Lateral Ventricle Development MAP-kinase Scaffold Activity Golgi-associated Vesicle Membrane
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