CFAP119 and KAT8

		CFAP119	KAT8
Description		cilia and flagella associated protein 119	lysine acetyltransferase 8
Image		No pdb structure
GO Annotations	Cellular Component	Radial Spoke Acrosomal Vesicle Cytoplasm Cilium Axoneme Cytoplasmic Vesicle Motile Cilium Cell Projection Sperm Principal Piece	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex
	Molecular Function		Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Single Fertilization Gene Expression Sperm Flagellum Assembly	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription
Pathways			HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes			15 interacting genes: ATM BAZ1B BAZ2A CEBPA FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		90835	84148
HPRD ID		18705	11381
Ensembl ID		ENSG00000196118	ENSG00000103510
Uniprot IDs		A1A4V9 H3BTQ9	Q9H7Z6
PDB IDs			2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Protein Propionyltransferase Activity Negative Regulation Of Short-term Synaptic Potentiation Negative Regulation Of SNARE Complex Assembly Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion MSL Complex Negative Regulation Of Vesicle Fusion Post-embryonic Hemopoiesis NSL Complex Skeletal Muscle Satellite Cell Differentiation Histone H4K8 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Mitochondrial Transcription Vesicle Fusion To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Histone H4 Acetyltransferase Activity Neuromuscular Process Controlling Posture Synaptic Vesicle Membrane Organization Regulation Of SNARE Complex Assembly Syntaxin-1 Binding Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Acetyltransferase Activity Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Skeletal Muscle Cell Differentiation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity NuA4 Histone Acetyltransferase Complex MLL1 Complex Histone Acetyltransferase Activity Regulation Of Vesicle Fusion Nuclear Lumen Oogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Type I Interferon Production Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Axon Terminus Skeletal Muscle Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Female Gamete Generation Positive Regulation Of Transcription Initiation By RNA Polymerase II Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Epithelial To Mesenchymal Transition Positive Regulation Of Type I Interferon Production	Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway
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