CLDN9 and STX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN9	STX8
Description		claudin 9	syntaxin 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Cell Junction Anchoring Junction	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Symbiont Entry Into Host Cell Bicellular Tight Junction Assembly Tight Junction Organization	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways		Tight junction interactions
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		17 interacting genes: ADIPOQ AOC3 ARLN BNIP3 CYB561 EMP1 ERMP1 EXTL1 GRM2 IGFBP5 LPAR3 MAL MALL PLPP6 RPRM STX8 VSTM1	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		9080	9482
HPRD ID		13071	05012
Ensembl ID		ENSG00000213937	ENSG00000170310
Uniprot IDs		O95484	Q9UNK0
PDB IDs		6OV2 6OV3
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Bleb Assembly Structural Constituent Of Myelin Sheath Membrane Chemical Homeostasis Brown Fat Cell Differentiation Mitochondrion Autophagosome Adaptor Activity Negative Regulation Of Synaptic Transmission Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Homeostatic Process	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly
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