SLC7A6 and DOLK

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SLC7A6	DOLK
Name		solute carrier family 7 member 6	dolichol kinase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Arginine Binding L-arginine Transmembrane Transporter Activity L-lysine:L-arginine Antiporter Activity	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process	Amino Acid Transmembrane Transport Nitric Oxide Biosynthetic Process Amino Acid Transport Neutral Amino Acid Transport L-leucine Transport Ornithine Transport Glycine Betaine Transport Transmembrane Transport L-lysine Transmembrane Transport L-arginine Transmembrane Transport	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Basigin interactions Amino acid transport across the plasma membrane	Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Diseases		None	Congenital disorders of glycosylation (CDG) type I
GWAS		Body mass index ( 28552196 ) Estimated glomerular filtration rate ( 30604766 31152163 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Metabolic traits ( 21886157 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 30285260 ) Serum metabolite levels ( 23093944 33031748 )	No GWAS studies recorded
Interacting Genes		1 interacting genes: DOLK	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		9057	22845
HPRD ID		12031	15525
Ensembl ID		ENSG00000103064	ENSG00000175283
Uniprot IDs		Q92536	A0A0S2Z597 Q9UPQ8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Dolichol Kinase Activity Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Isoprenoid Biosynthetic Process Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Glycolipid Biosynthetic Process Protein N-linked Glycosylation Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Phospholipid Metabolic Process	Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway