ATP6V1E2 and ATP6V1G1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, proximity labelling technology, affinity chromatography technology)

		ATP6V1E2	ATP6V1G1
Description		ATPase H+ transporting V1 subunit E2	ATPase H+ transporting V1 subunit G1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Proton-transporting Two-sector ATPase Complex, Catalytic Domain	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Monoatomic Ion Transport Regulation Of Macroautophagy Proton Transmembrane Transport	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid	Tiludronic acid
Diseases
GWAS		Anti-saccade error rate in psychotic disorders ( 29064472) Anti-saccade response ( 29064472) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bone mineral density (hip) and age at menarche ( 26312577) Bone mineral density (spine) and age at menarche ( 26312577)
Interacting Genes		5 interacting genes: ATP6V1G1 ATP6V1G2 BBLN MESD RASSF10	14 interacting genes: AP2B1 APP ATP6V1E1 ATP6V1E2 BCL2L11 GOLGA2 GOLGA6L9 GORASP2 LDOC1 LHX3 MAGEA6 NTAQ1 PNMA1 UBQLN2
Entrez ID		90423	9550
HPRD ID		16525	06294
Ensembl ID		ENSG00000250565	ENSG00000136888
Uniprot IDs		A0A140VKA8 Q96A05	O75348
PDB IDs			6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Extrinsic Component Of Synaptic Vesicle Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Proton-transporting ATPase Activity, Rotational Mechanism Neuron Cellular Homeostasis Synaptic Vesicle Membrane Subapical Part Of Cell Proton Transmembrane Transport Multinuclear Osteoclast Differentiation Regulation Of Macroautophagy Proton-transporting V-type ATPase, V1 Domain Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Intermediate Filament Bundle Assembly Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Homeostatic Process Cellular Response To Increased Oxygen Levels ATPase Complex Positive Regulation Of Receptor Clustering Regulation Of Autophagy ATP Hydrolysis Activity Proton-transporting V-type ATPase Complex Regulation Of Receptor Clustering Kinetochore Microtubule	Proton-transporting Two-sector ATPase Complex, Catalytic Domain Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagy Regulation Of Response To Endoplasmic Reticulum Stress Proton-transporting ATPase Activity, Rotational Mechanism Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Macroautophagy Cis-Golgi Network BIM-BCL-2 Complex Response To Endoplasmic Reticulum Stress BIM-BCL-xl Complex Protein-N-terminal Glutamine Amidohydrolase Activity
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