CH25H and KRTAP12-4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CH25H	KRTAP12-4
Description		cholesterol 25-hydroxylase	keratin associated protein 12-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Cytosol Intermediate Filament
	Molecular Function	C-4 Methylsterol Oxidase Activity Cholesterol 25-hydroxylase Activity Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Oxidoreductase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Response To Type I Interferon B Cell Chemotaxis Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Fusion Of Virus Membrane With Host Plasma Membrane
Pathways		Synthesis of bile acids and bile salts	Keratinization
Drugs
Diseases
GWAS		Atrioventricular conduction ( 21041692) Heart failure ( 20445134)
Interacting Genes		4 interacting genes: CCR4 GPR35 KRTAP12-4 OTX1	51 interacting genes: AQP1 ARID5A ATXN1 ATXN2L CH25H CYSRT1 FBXO34 GPRIN2 HMGB4 HOXA1 IQUB KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP6-2 KRTAP8-1 LASP1 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2C LCE3A LCE3D LCE4A LCE5A MEOX2 MGAT5B NBPF19 NOTCH2NLA NR4A3 OLIG2 OTX1 PIH1D2 POU4F2 RBPMS RERE SMCP SPMIP9 SSC4D TEKT5 TRIP13 VENTX
Entrez ID		9023	386684
HPRD ID		05183	11200
Ensembl ID		ENSG00000138135	ENSG00000212933
Uniprot IDs		O95992	P60329
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Diencephalon Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Metencephalon Development C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Interneuron Migration G Protein-coupled Receptor Activity Cytokine-mediated Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Tolerance Induction C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Transporter Activity	Keratinization Epidermis Development Intermediate Filament Tissue Development Identical Protein Binding Keratin Filament Protein Binding Sequence-specific DNA Binding Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
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