TNFSF18 and XCL1

		TNFSF18	XCL1
Description		TNF superfamily member 18	X-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Migration Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		TNFs bind their physiological receptors	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 27182965 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 22057235 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Psoriasis ( 34927100)
Interacting Genes		2 interacting genes: EXOC3L2 TNFRSF18	19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1
Entrez ID		8995	6375
HPRD ID		04874	02595
Ensembl ID		ENSG00000120337	ENSG00000143184
Uniprot IDs		A0A0U5JXL4 Q9UNG2	P47992
PDB IDs		2Q1M 2R30 2R32 3B93 3B94 7KHD 7LAW	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Leukocyte Migration Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Tumor Necrosis Factor Receptor Activity Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Adhesion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Exocyst Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Locomotion Cellular Response To Interleukin-4 Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Response To Interleukin-4 Positive Regulation Of T Cell Cytokine Production	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication
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